Boeckler FM - Search Results

1

Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3.

Muth F, El-Gokha A, Ansideri F, Eitel M, Döring E, Sievers-Engler A, Lange A, Boeckler FM, Lämmerhofer M, Koch P, Laufer SA. Muth F, et al. Among authors: boeckler fm. J Med Chem. 2017 Jan 26;60(2):594-607. doi: 10.1021/acs.jmedchem.6b01180. Epub 2017 Jan 17. J Med Chem. 2017. PMID: 27977190

2

CoMFA and CoMSIA investigations of dopamine D3 receptor ligands leading to the prediction, synthesis, and evaluation of rigidized FAUC 365 analogues.

Salama I, Schlotter K, Utz W, Hübner H, Gmeiner P, Boeckler F. Salama I, et al. Bioorg Med Chem. 2006 Sep 1;14(17):5898-912. doi: 10.1016/j.bmc.2006.05.025. Epub 2006 Jun 5. Bioorg Med Chem. 2006. PMID: 16750374

3

Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands.

Salama I, Hocke C, Utz W, Prante O, Boeckler F, Hübner H, Kuwert T, Gmeiner P. Salama I, et al. J Med Chem. 2007 Feb 8;50(3):489-500. doi: 10.1021/jm0611152. J Med Chem. 2007. PMID: 17266201

4

Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.

Mohamed HA, Girgis NM, Wilcken R, Bauer MR, Tinsley HN, Gary BD, Piazza GA, Boeckler FM, Abadi AH. Mohamed HA, et al. Among authors: boeckler fm. J Med Chem. 2011 Jan 27;54(2):495-509. doi: 10.1021/jm100842v. Epub 2010 Dec 28. J Med Chem. 2011. PMID: 21189023 Free PMC article.

5

Tri- and tetrasubstituted pyrazole derivates: regioisomerism switches activity from p38MAP kinase to important cancer kinases.

Abu Thaher B, Arnsmann M, Totzke F, Ehlert JE, Kubbutat MH, Schächtele C, Zimmermann MO, Koch P, Boeckler FM, Laufer SA. Abu Thaher B, et al. Among authors: boeckler fm. J Med Chem. 2012 Jan 26;55(2):961-5. doi: 10.1021/jm201391u. Epub 2012 Jan 17. J Med Chem. 2012. PMID: 22185282

6

Using halogen bonds to address the protein backbone: a systematic evaluation.

Wilcken R, Zimmermann MO, Lange A, Zahn S, Boeckler FM. Wilcken R, et al. Among authors: boeckler fm. J Comput Aided Mol Des. 2012 Aug;26(8):935-45. doi: 10.1007/s10822-012-9592-8. Epub 2012 Aug 4. J Comput Aided Mol Des. 2012. PMID: 22865255

7

Principles and applications of halogen bonding in medicinal chemistry and chemical biology.

Wilcken R, Zimmermann MO, Lange A, Joerger AC, Boeckler FM. Wilcken R, et al. Among authors: boeckler fm. J Med Chem. 2013 Feb 28;56(4):1363-88. doi: 10.1021/jm3012068. Epub 2013 Jan 3. J Med Chem. 2013. PMID: 23145854 Free article.

8

Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.

Fischer S, Wentsch HK, Mayer-Wrangowski SC, Zimmermann M, Bauer SM, Storch K, Niess R, Koeberle SC, Grütter C, Boeckler FM, Rauh D, Laufer SA. Fischer S, et al. Among authors: boeckler fm. J Med Chem. 2013 Jan 10;56(1):241-53. doi: 10.1021/jm301539x. Epub 2012 Dec 27. J Med Chem. 2013. PMID: 23270382

9

Targeting histidine side chains in molecular design through nitrogen-halogen bonds.

Lange A, Zimmermann MO, Wilcken R, Zahn S, Boeckler FM. Lange A, et al. Among authors: boeckler fm. J Chem Inf Model. 2013 Dec 23;53(12):3178-89. doi: 10.1021/ci4004305. Epub 2013 Nov 25. J Chem Inf Model. 2013. PMID: 24127844

10

Trisubstituted and tetrasubstituted pyrazolines as a novel class of cell-growth inhibitors in tumor cells with wild type p53.

Abdel-Halim M, Keeton AB, Gurpinar E, Gary BD, Vogel SM, Engel M, Piazza GA, Boeckler FM, Hartmann RW, Abadi AH. Abdel-Halim M, et al. Among authors: boeckler fm. Bioorg Med Chem. 2013 Dec 1;21(23):7343-56. doi: 10.1016/j.bmc.2013.09.055. Epub 2013 Oct 1. Bioorg Med Chem. 2013. PMID: 24139845

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