Laufer SA - Search Results

1

Tri- and Tetrasubstituted Pyridinylimidazoles as Covalent Inhibitors of c-Jun N-Terminal Kinase 3.

Muth F, El-Gokha A, Ansideri F, Eitel M, Döring E, Sievers-Engler A, Lange A, Boeckler FM, Lämmerhofer M, Koch P, Laufer SA. Muth F, et al. Among authors: laufer sa. J Med Chem. 2017 Jan 26;60(2):594-607. doi: 10.1021/acs.jmedchem.6b01180. Epub 2017 Jan 17. J Med Chem. 2017. PMID: 27977190

2

(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.

Laufer SA, Augustin J, Dannhardt G, Kiefer W. Laufer SA, et al. J Med Chem. 1994 Jun 10;37(12):1894-7. doi: 10.1021/jm00038a021. J Med Chem. 1994. PMID: 8021931

3

From imidazoles to pyrimidines: new inhibitors of cytokine release.

Laufer SA, Wagner GK. Laufer SA, et al. J Med Chem. 2002 Jun 20;45(13):2733-40. doi: 10.1021/jm011098a. J Med Chem. 2002. PMID: 12061876

4

Imidazole inhibitors of cytokine release: probing substituents in the 2 position.

Laufer SA, Striegel HG, Wagner GK. Laufer SA, et al. J Med Chem. 2002 Oct 10;45(21):4695-705. doi: 10.1021/jm020873z. J Med Chem. 2002. PMID: 12361396

5

Identification of regioisomers in a series of N-substituted pyridin-4-yl imidazole derivatives by regiospecific synthesis, GC/MS, and 1H NMR.

Wagner GK, Kotschenreuther D, Zimmermann W, Laufer SA. Wagner GK, et al. Among authors: laufer sa. J Org Chem. 2003 May 30;68(11):4527-30. doi: 10.1021/jo026619w. J Org Chem. 2003. PMID: 12762762

6

Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.

Laufer SA, Wagner GK, Kotschenreuther DA, Albrecht W. Laufer SA, et al. J Med Chem. 2003 Jul 17;46(15):3230-44. doi: 10.1021/jm030766k. J Med Chem. 2003. PMID: 12852754

7

Tetrasubstituted imidazole inhibitors of cytokine release: probing substituents in the N-1 position.

Laufer SA, Zimmermann W, Ruff KJ. Laufer SA, et al. J Med Chem. 2004 Dec 2;47(25):6311-25. doi: 10.1021/jm0496584. J Med Chem. 2004. PMID: 15566301

8

Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors.

Laufer SA, Domeyer DM, Scior TR, Albrecht W, Hauser DR. Laufer SA, et al. J Med Chem. 2005 Feb 10;48(3):710-22. doi: 10.1021/jm0408767. J Med Chem. 2005. PMID: 15689155

9

New approaches to the treatment of inflammatory disorders small molecule inhibitors of p38 MAP kinase.

Peifer C, Wagner G, Laufer S. Peifer C, et al. Curr Top Med Chem. 2006;6(2):113-49. doi: 10.2174/156802606775270323. Curr Top Med Chem. 2006. PMID: 16454763 Review.

10

Substituted isoxazoles as potent inhibitors of p38 MAP kinase.

Laufer SA, Margutti S, Fritz MD. Laufer SA, et al. ChemMedChem. 2006 Feb;1(2):197-207. doi: 10.1002/cmdc.200500025. ChemMedChem. 2006. PMID: 16892352

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