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Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications.
Shia J, Schultz N, Kuk D, Vakiani E, Middha S, Segal NH, Hechtman JF, Berger MF, Stadler ZK, Weiser MR, Wolchok JD, Boland CR, Gönen M, Klimstra DS. Shia J, et al. Among authors: middha s. Mod Pathol. 2017 Apr;30(4):599-609. doi: 10.1038/modpathol.2016.198. Epub 2016 Dec 16. Mod Pathol. 2017. PMID: 27982025 Free PMC article.
Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.
Yaeger R, Chatila WK, Lipsyc MD, Hechtman JF, Cercek A, Sanchez-Vega F, Jayakumaran G, Middha S, Zehir A, Donoghue MTA, You D, Viale A, Kemeny N, Segal NH, Stadler ZK, Varghese AM, Kundra R, Gao J, Syed A, Hyman DM, Vakiani E, Rosen N, Taylor BS, Ladanyi M, Berger MF, Solit DB, Shia J, Saltz L, Schultz N. Yaeger R, et al. Among authors: middha s. Cancer Cell. 2018 Jan 8;33(1):125-136.e3. doi: 10.1016/j.ccell.2017.12.004. Cancer Cell. 2018. PMID: 29316426 Free PMC article.
Retained mismatch repair protein expression occurs in approximately 6% of microsatellite instability-high cancers and is associated with missense mutations in mismatch repair genes.
Hechtman JF, Rana S, Middha S, Stadler ZK, Latham A, Benayed R, Soslow R, Ladanyi M, Yaeger R, Zehir A, Shia J. Hechtman JF, et al. Among authors: middha s. Mod Pathol. 2020 May;33(5):871-879. doi: 10.1038/s41379-019-0414-6. Epub 2019 Dec 19. Mod Pathol. 2020. PMID: 31857677 Free PMC article.
Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival.
Ptashkin RN, Pagan C, Yaeger R, Middha S, Shia J, O'Rourke KP, Berger MF, Wang L, Cimera R, Wang J, Klimstra DS, Saltz L, Ladanyi M, Zehir A, Hechtman JF. Ptashkin RN, et al. Among authors: middha s. Mol Cancer Res. 2017 Jun;15(6):708-713. doi: 10.1158/1541-7786.MCR-16-0352. Epub 2017 Feb 9. Mol Cancer Res. 2017. PMID: 28184012 Free PMC article.
Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF.
Hechtman JF, Zehir A, Yaeger R, Wang L, Middha S, Zheng T, Hyman DM, Solit D, Arcila ME, Borsu L, Shia J, Vakiani E, Saltz L, Ladanyi M. Hechtman JF, et al. Among authors: middha s. Mol Cancer Res. 2016 Mar;14(3):296-301. doi: 10.1158/1541-7786.MCR-15-0392-T. Epub 2015 Dec 11. Mol Cancer Res. 2016. PMID: 26660078 Free PMC article.
Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels.
Stadler ZK, Battaglin F, Middha S, Hechtman JF, Tran C, Cercek A, Yaeger R, Segal NH, Varghese AM, Reidy-Lagunes DL, Kemeny NE, Salo-Mullen EE, Ashraf A, Weiser MR, Garcia-Aguilar J, Robson ME, Offit K, Arcila ME, Berger MF, Shia J, Solit DB, Saltz LB. Stadler ZK, et al. Among authors: middha s. J Clin Oncol. 2016 Jun 20;34(18):2141-7. doi: 10.1200/JCO.2015.65.1067. Epub 2016 Mar 28. J Clin Oncol. 2016. PMID: 27022117 Free PMC article.
Recurrent, truncating SOX9 mutations are associated with SOX9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma.
Javier BM, Yaeger R, Wang L, Sanchez-Vega F, Zehir A, Middha S, Sadowska J, Vakiani E, Shia J, Klimstra D, Ladanyi M, Iacobuzio-Donahue CA, Hechtman JF. Javier BM, et al. Among authors: middha s. Oncotarget. 2016 Aug 9;7(32):50875-50882. doi: 10.18632/oncotarget.9682. Oncotarget. 2016. PMID: 27248473 Free PMC article.
The genetic landscape of endometrial clear cell carcinomas.
DeLair DF, Burke KA, Selenica P, Lim RS, Scott SN, Middha S, Mohanty AS, Cheng DT, Berger MF, Soslow RA, Weigelt B. DeLair DF, et al. Among authors: middha s. J Pathol. 2017 Oct;243(2):230-241. doi: 10.1002/path.4947. Epub 2017 Sep 5. J Pathol. 2017. PMID: 28718916 Free PMC article.
144 results