O'Farrelly C - Search Results

1

A novel anti-viral role for STAT3 in IFN-α signalling responses.

Mahony R, Gargan S, Roberts KL, Bourke N, Keating SE, Bowie AG, O'Farrelly C, Stevenson NJ. Mahony R, et al. Cell Mol Life Sci. 2017 May;74(9):1755-1764. doi: 10.1007/s00018-016-2435-3. Epub 2016 Dec 17. Cell Mol Life Sci. 2017. PMID: 27988795 Free PMC article.

2

Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection.

Ryan EJ, Dring M, Ryan CM, McNulty C, Stevenson NJ, Lawless MW, Crowe J, Nolan N, Hegarty JE, O'Farrelly C. Ryan EJ, et al. Hum Immunol. 2010 Aug;71(8):829-32. doi: 10.1016/j.humimm.2010.05.007. Epub 2010 May 12. Hum Immunol. 2010. PMID: 20470843

3

Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11.

Stevenson NJ, McFarlane C, Ong ST, Nahlik K, Kelvin A, Addley MR, Long A, Greaves DR, O'Farrelly C, Johnston JA. Stevenson NJ, et al. FEBS Lett. 2010 Nov 5;584(21):4469-74. doi: 10.1016/j.febslet.2010.10.007. Epub 2010 Oct 8. FEBS Lett. 2010. PMID: 20934424 Free article.

4

Ribavirin enhances IFN-α signalling and MxA expression: a novel immune modulation mechanism during treatment of HCV.

Stevenson NJ, Murphy AG, Bourke NM, Keogh CA, Hegarty JE, O'Farrelly C. Stevenson NJ, et al. PLoS One. 2011;6(11):e27866. doi: 10.1371/journal.pone.0027866. Epub 2011 Nov 16. PLoS One. 2011. PMID: 22114715 Free PMC article.

5

Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.

Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C. Stevenson NJ, et al. FEBS Lett. 2013 May 21;587(10):1571-8. doi: 10.1016/j.febslet.2013.03.041. Epub 2013 Apr 12. FEBS Lett. 2013. PMID: 23587486 Free article.

6

miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling.

Collins AS, McCoy CE, Lloyd AT, O'Farrelly C, Stevenson NJ. Collins AS, et al. PLoS One. 2013 Jul 22;8(7):e69090. doi: 10.1371/journal.pone.0069090. Print 2013. PLoS One. 2013. PMID: 23894411 Free PMC article.

7

Hepatitis C virus (HCV)-induced suppressor of cytokine signaling (SOCS) 3 regulates proinflammatory TNF-α responses.

Collins AS, Ahmed S, Napoletano S, Schroeder M, Johnston JA, Hegarty JE, O'Farrelly C, Stevenson NJ. Collins AS, et al. J Leukoc Biol. 2014 Aug;96(2):255-63. doi: 10.1189/jlb.2A1211-608RRRR. Epub 2014 Mar 21. J Leukoc Biol. 2014. PMID: 24659790 Clinical Trial.

8

In vitro blood cell responsiveness to IFN-α predicts clinical response independently of IL28B in hepatitis C virus genotype 1 infected patients.

Bourke NM, O'Neill MT, Sarwar S, Norris S, Stewart S, Hegarty JE, Stevenson NJ, O'Farrelly C. Bourke NM, et al. J Transl Med. 2014 Jul 21;12:206. doi: 10.1186/1479-5876-12-206. J Transl Med. 2014. PMID: 25048205 Free PMC article.

9

HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction.

Gargan S, Ahmed S, Mahony R, Bannan C, Napoletano S, O'Farrelly C, Borrow P, Bergin C, Stevenson NJ. Gargan S, et al. EBioMedicine. 2018 Apr;30:203-216. doi: 10.1016/j.ebiom.2018.03.006. Epub 2018 Mar 9. EBioMedicine. 2018. PMID: 29580840 Free PMC article.

10

The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)-α via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK)-mediated induction of suppressor of cytokine signaling (SOCS)3.

Convery O, Gargan S, Kickham M, Schroder M, O'Farrelly C, Stevenson NJ. Convery O, et al. FASEB J. 2019 Aug;33(8):8732-8744. doi: 10.1096/fj.201800629RR. Epub 2019 Jun 4. FASEB J. 2019. PMID: 31163989

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