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Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference.
Goodship TH, Cook HT, Fakhouri F, Fervenza FC, Frémeaux-Bacchi V, Kavanagh D, Nester CM, Noris M, Pickering MC, Rodríguez de Córdoba S, Roumenina LT, Sethi S, Smith RJ; Conference Participants. Goodship TH, et al. Among authors: roumenina lt. Kidney Int. 2017 Mar;91(3):539-551. doi: 10.1016/j.kint.2016.10.005. Epub 2016 Dec 16. Kidney Int. 2017. PMID: 27989322 Free article.
Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome.
Roumenina LT, Jablonski M, Hue C, Blouin J, Dimitrov JD, Dragon-Durey MA, Cayla M, Fridman WH, Macher MA, Ribes D, Moulonguet L, Rostaing L, Satchell SC, Mathieson PW, Sautes-Fridman C, Loirat C, Regnier CH, Halbwachs-Mecarelli L, Fremeaux-Bacchi V. Roumenina LT, et al. Blood. 2009 Sep 24;114(13):2837-45. doi: 10.1182/blood-2009-01-197640. Epub 2009 Jul 7. Blood. 2009. PMID: 19584399 Free article.
Alternative complement pathway assessment in patients with atypical HUS.
Roumenina LT, Loirat C, Dragon-Durey MA, Halbwachs-Mecarelli L, Sautes-Fridman C, Fremeaux-Bacchi V. Roumenina LT, et al. J Immunol Methods. 2011 Feb 28;365(1-2):8-26. doi: 10.1016/j.jim.2010.12.020. Epub 2011 Jan 6. J Immunol Methods. 2011. PMID: 21215749 Review.
Heme interacts with c1q and inhibits the classical complement pathway.
Roumenina LT, Radanova M, Atanasov BP, Popov KT, Kaveri SV, Lacroix-Desmazes S, Frémeaux-Bacchi V, Dimitrov JD. Roumenina LT, et al. J Biol Chem. 2011 May 6;286(18):16459-69. doi: 10.1074/jbc.M110.206136. Epub 2011 Mar 22. J Biol Chem. 2011. PMID: 21454703 Free PMC article.
129 results