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Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.
Suzuki H, Ito Y, Shinohara M, Yamashita S, Ichinose S, Kishida A, Oyaizu T, Kayama T, Nakamichi R, Koda N, Yagishita K, Lotz MK, Okawa A, Asahara H. Suzuki H, et al. Among authors: ito y. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7840-5. doi: 10.1073/pnas.1522054113. Epub 2016 Jul 1. Proc Natl Acad Sci U S A. 2016. PMID: 27370800 Free PMC article.
The Mohawk homeobox gene is a critical regulator of tendon differentiation.
Ito Y, Toriuchi N, Yoshitaka T, Ueno-Kudoh H, Sato T, Yokoyama S, Nishida K, Akimoto T, Takahashi M, Miyaki S, Asahara H. Ito Y, et al. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10538-42. doi: 10.1073/pnas.1000525107. Epub 2010 May 24. Proc Natl Acad Sci U S A. 2010. PMID: 20498044 Free PMC article.
In vitro Neo-Genesis of Tendon/Ligament-Like Tissue by Combination of Mohawk and a Three-Dimensional Cyclic Mechanical Stretch Culture System.
Kataoka K, Kurimoto R, Tsutsumi H, Chiba T, Kato T, Shishido K, Kato M, Ito Y, Cho Y, Hoshi O, Mimata A, Sakamaki Y, Nakamichi R, Lotz MK, Naruse K, Asahara H. Kataoka K, et al. Among authors: ito y. Front Cell Dev Biol. 2020 Jun 2;8:307. doi: 10.3389/fcell.2020.00307. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32671057 Free PMC article.
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