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Page 1
Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice.
Wiehe K, Nicely NI, Lockwood B, Kuraoka M, Anasti K, Arora S, Bowman CM, Stolarchuk C, Parks R, Lloyd KE, Xia SM, Duffy R, Shen X, Kyratsous CA, Macdonald LE, Murphy AJ, Scearce RM, Moody MA, Alam SM, Verkoczy L, Tomaras GD, Kelsoe G, Haynes BF. Wiehe K, et al. Among authors: kyratsous ca. J Immunol. 2017 Feb 1;198(3):1047-1055. doi: 10.4049/jimmunol.1601640. Epub 2016 Dec 23. J Immunol. 2017. PMID: 28011932 Free PMC article.
Genetic risk factors for COVID-19 and influenza are largely distinct.
Kosmicki JA, Marcketta A, Sharma D, Di Gioia SA, Batista S, Yang XM, Tzoneva G, Martinez H, Sidore C, Kessler MD, Horowitz JE, Roberts GHL, Justice AE, Banerjee N, Coignet MV, Leader JB, Park DS, Lanche R, Maxwell E, Knight SC, Bai X, Guturu H, Baltzell A, Girshick AR, McCurdy SR, Partha R, Mansfield AJ, Turissini DA, Zhang M, Mbatchou J, Watanabe K, Verma A, Sirugo G; Colorado Center for Precision Medicine; Mayo Clinic Project Generation; Regeneron Genetics Center; University of California Los Angeles ATLAS Collaboration; Ritchie MD, Salerno WJ, Shuldiner AR, Rader DJ, Mirshahi T, Marchini J, Overton JD, Carey DJ, Habegger L, Reid JG, Economides A, Kyratsous C, Karalis K, Baum A, Cantor MN, Rand KA, Hong EL, Ball CA, Siminovitch K, Baras A, Abecasis GR, Ferreira MAR. Kosmicki JA, et al. Among authors: kyratsous c. Nat Genet. 2024 Aug;56(8):1592-1596. doi: 10.1038/s41588-024-01844-1. Epub 2024 Aug 5. Nat Genet. 2024. PMID: 39103650 Free PMC article.
A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells.
Cruz JW, Damko E, Modi B, Tu N, Meagher K, Voronina V, Gartner H, Ehrlich G, Rafique A, Babb R, Aneja P, Potocky TB, D' Orvilliers A, Coppi A, E SY, Qiu H, Williams CM, Bennett BL, Chen G, Macdonald L, Olson W, Lin JC, Stahl N, Murphy AJ, Kyratsous CA, Prasad BC. Cruz JW, et al. Among authors: kyratsous ca. Sci Rep. 2019 Aug 19;9(1):12031. doi: 10.1038/s41598-019-48461-1. Sci Rep. 2019. PMID: 31427700 Free PMC article.
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.
Hansen J, Baum A, Pascal KE, Russo V, Giordano S, Wloga E, Fulton BO, Yan Y, Koon K, Patel K, Chung KM, Hermann A, Ullman E, Cruz J, Rafique A, Huang T, Fairhurst J, Libertiny C, Malbec M, Lee WY, Welsh R, Farr G, Pennington S, Deshpande D, Cheng J, Watty A, Bouffard P, Babb R, Levenkova N, Chen C, Zhang B, Romero Hernandez A, Saotome K, Zhou Y, Franklin M, Sivapalasingam S, Lye DC, Weston S, Logue J, Haupt R, Frieman M, Chen G, Olson W, Murphy AJ, Stahl N, Yancopoulos GD, Kyratsous CA. Hansen J, et al. Among authors: kyratsous ca. Science. 2020 Aug 21;369(6506):1010-1014. doi: 10.1126/science.abd0827. Epub 2020 Jun 15. Science. 2020. PMID: 32540901 Free PMC article.
Humanization of T cell-mediated immunity in mice.
Moore MJ, Zhong M, Hansen J, Gartner H, Grant C, Huang M, Harris FM, Tu N, Bowerman NA, Edelmann KH, Barry T, Herbin O, Tay CS, DiLillo DJ, Decker CE, Levenkova N, Shevchuk J, Dhanik A, Meagher KA, Karr A, Roos J, Lee WY, Suh D, Eckersdorff M, Meagher TC, Koss M, Esau L, Sleeman MA, Babb R, Chen G, Kyratsous CA, Poueymirou WT, McWhirter JR, Voronina VA, Guo C, Gurer C, Yancopoulos GD, Murphy AJ, Macdonald LE. Moore MJ, et al. Among authors: kyratsous ca. Sci Immunol. 2021 Dec 17;6(66):eabj4026. doi: 10.1126/sciimmunol.abj4026. Epub 2021 Dec 17. Sci Immunol. 2021. PMID: 34919442
Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054.
Tavaré R, Danton M, Giurleo JT, Makonnen S, Hickey C, Arnold TC, Kelly MP, Fredriksson F, Bruestle K, Hermann A, Ullman E, Edelmann KH, Potocky T, Dudgeon D, Bhatt NB, Doubrovin M, Barry T, Kyratsous CA, Gurer C, Tu N, Gartner H, Murphy A, Macdonald LE, Popke J, Mintz A, Griesemer A, Olson WC, Thurston G, Ma D, Kirshner JR. Tavaré R, et al. Among authors: kyratsous ca. Cancer Immunol Res. 2022 Oct 4;10(10):1190-1209. doi: 10.1158/2326-6066.CIR-21-0405. Cancer Immunol Res. 2022. PMID: 35895745 Free PMC article.
IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models.
Carbonaro M, Wang K, Huang H, Frleta D, Patel A, Pennington A, Desclaux M, Moller-Tank S, Grindley J, Altarejos J, Zhong J, Polites G, Poueymirou W, Jaspers S, Kyratsous C, Zambrowicz B, Murphy A, Lin JC, Macdonald LE, Daly C, Sleeman M, Thurston G, Li Z. Carbonaro M, et al. Sci Adv. 2023 Apr 14;9(15):eadf4490. doi: 10.1126/sciadv.adf4490. Epub 2023 Apr 14. Sci Adv. 2023. PMID: 37058568 Free PMC article.
Monoclonal antibodies against the spike protein alter the endogenous humoral response to SARS-CoV-2 vaccination and infection.
Petro CD, Hooper AT, Peace A, Mohammadi K, Eagan W, Elbashir SM, DiPiazza A, Makrinos D, Pascal K, Bandawane P, Durand M, Basu R, Coppi A, Wang B, Golubov J, Asrat S, Ganguly S, Koehler-Stec EM, Wipperman MF, Ehrlich G, Gonzalez Ortiz AM, Isa F, Lewis MG, Andersen H, Musser BJ, Torres M, Lee WY, Edwards D, Skokos D, Orengo J, Sleeman M, Norton T, O'Brien M, Forleo-Neto E, Herman GA, Hamilton JD, Murphy AJ, Kyratsous CA, Baum A. Petro CD, et al. Among authors: kyratsous ca. Sci Transl Med. 2024 Nov 6;16(772):eadn0396. doi: 10.1126/scitranslmed.adn0396. Epub 2024 Nov 6. Sci Transl Med. 2024. PMID: 39504352
64 results