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PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA. Lam AM, et al. Among authors: nagarathnam d. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. doi: 10.1128/AAC.00399-10. Epub 2010 Jun 1. Antimicrob Agents Chemother. 2010. PMID: 20516278 Free PMC article.
Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine.
Lam AM, Espiritu C, Murakami E, Zennou V, Bansal S, Micolochick Steuer HM, Niu C, Keilman M, Bao H, Bourne N, Veselenak RL, Reddy PG, Chang W, Du J, Nagarathnam D, Sofia MJ, Otto MJ, Furman PA. Lam AM, et al. Among authors: nagarathnam d. Antimicrob Agents Chemother. 2011 Jun;55(6):2566-75. doi: 10.1128/AAC.00032-11. Epub 2011 Mar 28. Antimicrob Agents Chemother. 2011. PMID: 21444700 Free PMC article.
Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection.
Chang W, Bao D, Chun BK, Naduthambi D, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Zhang HR, Bansal S, Espiritu CL, Keilman M, Lam AM, Niu C, Steuer HM, Furman PA, Otto MJ, Sofia MJ. Chang W, et al. Among authors: nagarathnam d. ACS Med Chem Lett. 2010 Dec 17;2(2):130-5. doi: 10.1021/ml100209f. eCollection 2011 Feb 10. ACS Med Chem Lett. 2010. PMID: 24900291 Free PMC article.
2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.
Reddy PG, Bao D, Chang W, Chun BK, Du J, Nagarathnam D, Rachakonda S, Ross BS, Zhang HR, Bansal S, Espiritu CL, Keilman M, Lam AM, Niu C, Steuer HM, Furman PA, Otto MJ, Sofia MJ. Reddy PG, et al. Among authors: nagarathnam d. Bioorg Med Chem Lett. 2010 Dec 15;20(24):7376-80. doi: 10.1016/j.bmcl.2010.10.035. Epub 2010 Oct 15. Bioorg Med Chem Lett. 2010. PMID: 21050754
Phenylacetamides as selective alpha-1A adrenergic receptor antagonists.
Patane MA, DiPardo RM, Newton RC, Price RP, Broten TP, Chang RS, Ransom RW, Di Salvo J, Nagarathnam D, Forray C, Gluchowski C, Bock MG. Patane MA, et al. Among authors: nagarathnam d. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1621-4. doi: 10.1016/s0960-894x(00)00307-3. Bioorg Med Chem Lett. 2000. PMID: 10937709
27 results