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Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1.
Hinchliffe P, Yang QE, Portal E, Young T, Li H, Tooke CL, Carvalho MJ, Paterson NG, Brem J, Niumsup PR, Tansawai U, Lei L, Li M, Shen Z, Wang Y, Schofield CJ, Mulholland AJ, Shen J, Fey N, Walsh TR, Spencer J. Hinchliffe P, et al. Among authors: portal e. Sci Rep. 2017 Jan 6;7:39392. doi: 10.1038/srep39392. Sci Rep. 2017. PMID: 28059088 Free PMC article.
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms.
Yang Q, Li M, Spiller OB, Andrey DO, Hinchliffe P, Li H, MacLean C, Niumsup P, Powell L, Pritchard M, Papkou A, Shen Y, Portal E, Sands K, Spencer J, Tansawai U, Thomas D, Wang S, Wang Y, Shen J, Walsh T. Yang Q, et al. Among authors: portal e. Nat Commun. 2017 Dec 12;8(1):2054. doi: 10.1038/s41467-017-02149-0. Nat Commun. 2017. PMID: 29233990 Free PMC article.
Characterization of antimicrobial-resistant Gram-negative bacteria that cause neonatal sepsis in seven low- and middle-income countries.
Sands K, Carvalho MJ, Portal E, Thomson K, Dyer C, Akpulu C, Andrews R, Ferreira A, Gillespie D, Hender T, Hood K, Mathias J, Milton R, Nieto M, Taiyari K, Chan GJ, Bekele D, Solomon S, Basu S, Chattopadhyay P, Mukherjee S, Iregbu K, Modibbo F, Uwaezuoke S, Zahra R, Shirazi H, Muhammad A, Mazarati JB, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A; BARNARDS Group; Walsh TR. Sands K, et al. Among authors: portal e. Nat Microbiol. 2021 Apr;6(4):512-523. doi: 10.1038/s41564-021-00870-7. Epub 2021 Mar 29. Nat Microbiol. 2021. PMID: 33782558 Free PMC article.
Effects of antibiotic resistance, drug target attainment, bacterial pathogenicity and virulence, and antibiotic access and affordability on outcomes in neonatal sepsis: an international microbiology and drug evaluation prospective substudy (BARNARDS).
Thomson KM, Dyer C, Liu F, Sands K, Portal E, Carvalho MJ, Barrell M, Boostrom I, Dunachie S, Farzana R, Ferreira A, Frayne F, Hassan B, Jones E, Jones L, Mathias J, Milton R, Rees J, Chan GJ, Bekele D, Mahlet A, Basu S, Nandy RK, Saha B, Iregbu K, Modibbo F, Uwaezuoke S, Zahra R, Shirazi H, Syed NU, Mazarati JB, Rucogoza A, Gaju L, Mehtar S, Bulabula ANH, Whitelaw A, van Hasselt JGC, Walsh TR; BARNARDS Group. Thomson KM, et al. Among authors: portal e. Lancet Infect Dis. 2021 Dec;21(12):1677-1688. doi: 10.1016/S1473-3099(21)00050-5. Epub 2021 Aug 9. Lancet Infect Dis. 2021. PMID: 34384533 Free PMC article.
38 results