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Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production.
van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Colin EM, Hazes JM, Dolhain RJ, Lubberts E. van Hamburg JP, et al. Arthritis Rheum. 2011 Jan;63(1):73-83. doi: 10.1002/art.30093. Arthritis Rheum. 2011. PMID: 20954258 Free article.
IL-17/Th17 mediated synovial inflammation is IL-22 independent.
van Hamburg JP, Corneth OB, Paulissen SM, Davelaar N, Asmawidjaja PS, Mus AM, Lubberts E. van Hamburg JP, et al. Ann Rheum Dis. 2013 Oct;72(10):1700-7. doi: 10.1136/annrheumdis-2012-202373. Epub 2013 Jan 17. Ann Rheum Dis. 2013. PMID: 23328939
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