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RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter.
Ko B, Kamsteeg EJ, Cooke LL, Moddes LN, Deen PM, Hoover RS. Ko B, et al. Am J Physiol Renal Physiol. 2010 Aug;299(2):F300-9. doi: 10.1152/ajprenal.00441.2009. Epub 2010 Apr 14. Am J Physiol Renal Physiol. 2010. PMID: 20392800 Free PMC article.
Recently, we described a novel pathway of NCC regulation in which phorbol esters (PE) stimulate Ras guanyl-releasing protein 1 (RasGRP1), triggering a cascade ultimately activating ERK1/2 MAPK and decreasing NCC cell surface expression (Ko B, Joshi LM, Cooke LL, Vaz …
Recently, we described a novel pathway of NCC regulation in which phorbol esters (PE) stimulate Ras guanyl-releasing protein 1 (RasGRP1), tr …
Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.
Arroyo JP, Lagnaz D, Ronzaud C, Vázquez N, Ko BS, Moddes L, Ruffieux-Daidié D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O. Arroyo JP, et al. Among authors: ko bs. J Am Soc Nephrol. 2011 Sep;22(9):1707-19. doi: 10.1681/ASN.2011020132. Epub 2011 Aug 18. J Am Soc Nephrol. 2011. PMID: 21852580 Free PMC article.
A new model of the distal convoluted tubule.
Ko B, Mistry AC, Hanson L, Mallick R, Cooke LL, Hack BK, Cunningham P, Hoover RS. Ko B, et al. Am J Physiol Renal Physiol. 2012 Sep;303(5):F700-10. doi: 10.1152/ajprenal.00139.2012. Epub 2012 Jun 20. Am J Physiol Renal Physiol. 2012. PMID: 22718890 Free PMC article.
Aldosterone acutely stimulates NCC activity via a SPAK-mediated pathway.
Ko B, Mistry AC, Hanson L, Mallick R, Wynne BM, Thai TL, Bailey JL, Klein JD, Hoover RS. Ko B, et al. Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F645-52. doi: 10.1152/ajprenal.00053.2013. Epub 2013 Jun 5. Am J Physiol Renal Physiol. 2013. PMID: 23739593 Free PMC article.
1,568 results