Chuang JL - Search Results

1

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

Tso SC, Lou M, Wu CY, Gui WJ, Chuang JL, Morlock LK, Williams NS, Wynn RM, Qi X, Chuang DT. Tso SC, et al. Among authors: chuang jl. J Med Chem. 2017 Feb 9;60(3):1142-1150. doi: 10.1021/acs.jmedchem.6b01540. Epub 2017 Jan 31. J Med Chem. 2017. PMID: 28085286 Free PMC article.

2

Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket.

Tso SC, Qi X, Gui WJ, Wu CY, Chuang JL, Wernstedt-Asterholm I, Morlock LK, Owens KR, Scherer PE, Williams NS, Tambar UK, Wynn RM, Chuang DT. Tso SC, et al. Among authors: chuang jl. J Biol Chem. 2014 Feb 14;289(7):4432-43. doi: 10.1074/jbc.M113.533885. Epub 2013 Dec 19. J Biol Chem. 2014. PMID: 24356970 Free PMC article.

3

Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice.

Wu CY, Tso SC, Chuang JL, Gui WJ, Lou M, Sharma G, Khemtong C, Qi X, Wynn RM, Chuang DT. Wu CY, et al. Among authors: chuang jl. Mol Metab. 2018 Jun;12:12-24. doi: 10.1016/j.molmet.2018.03.014. Epub 2018 Mar 31. Mol Metab. 2018. PMID: 29656110 Free PMC article.

4

Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.

Kato M, Chuang JL, Tso SC, Wynn RM, Chuang DT. Kato M, et al. Among authors: chuang jl, chuang dt. EMBO J. 2005 May 18;24(10):1763-74. doi: 10.1038/sj.emboj.7600663. Epub 2005 Apr 28. EMBO J. 2005. PMID: 15861126 Free PMC article.

5

Structural determinants for cross-talk between pyruvate dehydrogenase kinase 3 and lipoyl domain 2 of the human pyruvate dehydrogenase complex.

Tso SC, Kato M, Chuang JL, Chuang DT. Tso SC, et al. Among authors: chuang jl, chuang dt. J Biol Chem. 2006 Sep 15;281(37):27197-204. doi: 10.1074/jbc.M604339200. Epub 2006 Jul 18. J Biol Chem. 2006. PMID: 16849321 Free article.

6

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol.

Kato M, Li J, Chuang JL, Chuang DT. Kato M, et al. Among authors: chuang jl, chuang dt. Structure. 2007 Aug;15(8):992-1004. doi: 10.1016/j.str.2007.07.001. Epub 2007 Aug 2. Structure. 2007. PMID: 17683942 Free PMC article.

7

Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity.

Wynn RM, Kato M, Chuang JL, Tso SC, Li J, Chuang DT. Wynn RM, et al. Among authors: chuang jl, chuang dt. J Biol Chem. 2008 Sep 12;283(37):25305-25315. doi: 10.1074/jbc.M802249200. Epub 2008 Jul 24. J Biol Chem. 2008. PMID: 18658136 Free PMC article.

8

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.

Tso SC, Qi X, Gui WJ, Chuang JL, Morlock LK, Wallace AL, Ahmed K, Laxman S, Campeau PM, Lee BH, Hutson SM, Tu BP, Williams NS, Tambar UK, Wynn RM, Chuang DT. Tso SC, et al. Among authors: chuang jl. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9728-33. doi: 10.1073/pnas.1303220110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716694 Free PMC article.

9

Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase.

Tso SC, Gui WJ, Wu CY, Chuang JL, Qi X, Skvora KJ, Dork K, Wallace AL, Morlock LK, Lee BH, Hutson SM, Strom SC, Williams NS, Tambar UK, Wynn RM, Chuang DT. Tso SC, et al. Among authors: chuang jl. J Biol Chem. 2014 Jul 25;289(30):20583-93. doi: 10.1074/jbc.M114.569251. J Biol Chem. 2014. PMID: 24895126 Free PMC article.

10

Structural basis for inactivation of the human pyruvate dehydrogenase complex by phosphorylation: role of disordered phosphorylation loops.

Kato M, Wynn RM, Chuang JL, Tso SC, Machius M, Li J, Chuang DT. Kato M, et al. Among authors: chuang jl, chuang dt. Structure. 2008 Dec 10;16(12):1849-59. doi: 10.1016/j.str.2008.10.010. Structure. 2008. PMID: 19081061 Free PMC article.

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