Shirian J - Search Results

1

Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution.

Arkadash V, Yosef G, Shirian J, Cohen I, Horev Y, Grossman M, Sagi I, Radisky ES, Shifman JM, Papo N. Arkadash V, et al. Among authors: shirian j. J Biol Chem. 2017 Feb 24;292(8):3481-3495. doi: 10.1074/jbc.M116.756718. Epub 2017 Jan 13. J Biol Chem. 2017. PMID: 28087697 Free PMC article.

2

Predicting affinity- and specificity-enhancing mutations at protein-protein interfaces.

Sharabi O, Shirian J, Shifman JM. Sharabi O, et al. Among authors: shirian j. Biochem Soc Trans. 2013 Oct;41(5):1166-9. doi: 10.1042/BST20130121. Biochem Soc Trans. 2013. PMID: 24059503 Review.

3

Affinity- and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs.

Sharabi O, Shirian J, Grossman M, Lebendiker M, Sagi I, Shifman J. Sharabi O, et al. Among authors: shirian j. PLoS One. 2014 Apr 7;9(4):e93712. doi: 10.1371/journal.pone.0093712. eCollection 2014. PLoS One. 2014. PMID: 24710006 Free PMC article.

4

Combinatorial and Computational Approaches to Identify Interactions of Macrophage Colony-stimulating Factor (M-CSF) and Its Receptor c-FMS.

Rosenfeld L, Shirian J, Zur Y, Levaot N, Shifman JM, Papo N. Rosenfeld L, et al. Among authors: shirian j. J Biol Chem. 2015 Oct 23;290(43):26180-93. doi: 10.1074/jbc.M115.671271. Epub 2015 Sep 10. J Biol Chem. 2015. PMID: 26359491 Free PMC article.

5

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14.

Shirian J, Arkadash V, Cohen I, Sapir T, Radisky ES, Papo N, Shifman JM. Shirian J, et al. FEBS Lett. 2018 Apr;592(7):1122-1134. doi: 10.1002/1873-3468.13016. Epub 2018 Mar 12. FEBS Lett. 2018. PMID: 29473954 Free PMC article.

6

Cold Spots in Protein Binding.

Shirian J, Sharabi O, Shifman JM. Shirian J, et al. Trends Biochem Sci. 2016 Sep;41(9):739-745. doi: 10.1016/j.tibs.2016.07.002. Epub 2016 Jul 29. Trends Biochem Sci. 2016. PMID: 27477052

7

Climbing Up and Down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein-Protein Complexes.

Heyne M, Shirian J, Cohen I, Peleg Y, Radisky ES, Papo N, Shifman JM. Heyne M, et al. Among authors: shirian j. J Am Chem Soc. 2021 Oct 20;143(41):17261-17275. doi: 10.1021/jacs.1c08707. Epub 2021 Oct 5. J Am Chem Soc. 2021. PMID: 34609866 Free PMC article.

8

Mapping of the binding landscape for a picomolar protein-protein complex through computation and experiment.

Aizner Y, Sharabi O, Shirian J, Dakwar GR, Risman M, Avraham O, Shifman J. Aizner Y, et al. Among authors: shirian j. Structure. 2014 Apr 8;22(4):636-45. doi: 10.1016/j.str.2014.01.012. Epub 2014 Mar 6. Structure. 2014. PMID: 24613488 Free article.

9

Associations between Androgen Exposure, Polycystic Ovary Syndrome, and Transmasculine Individuals with Central Serous Chorioretinopathy.

Shirian JD, Shaia JK, Das N, Talcott KE, Singh RP, Mammo DA. Shirian JD, et al. Ophthalmol Retina. 2024 Nov 8:S2468-6530(24)00527-X. doi: 10.1016/j.oret.2024.10.026. Online ahead of print. Ophthalmol Retina. 2024. PMID: 39521133

10

Engineered TIMP2 with narrow MMP-9 specificity is an effective inhibitor of invasion and proliferation of triple-negative breast cancer cells.

Rotenberg N, Feldman M, Shirian J, Hockla A, Radisky ES, Shifman JM. Rotenberg N, et al. Among authors: shirian j. J Biol Chem. 2024 Nov;300(11):107867. doi: 10.1016/j.jbc.2024.107867. Epub 2024 Oct 15. J Biol Chem. 2024. PMID: 39419285 Free PMC article.

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