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Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα.
Hinds TD Jr, Hosick PA, Chen S, Tukey RH, Hankins MW, Nestor-Kalinoski A, Stec DE. Hinds TD Jr, et al. Among authors: chen s. Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E244-E252. doi: 10.1152/ajpendo.00396.2016. Epub 2017 Jan 17. Am J Physiol Endocrinol Metab. 2017. PMID: 28096081 Free PMC article.
Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.
Senekeo-Effenberger K, Chen S, Brace-Sinnokrak E, Bonzo JA, Yueh MF, Argikar U, Kaeding J, Trottier J, Remmel RP, Ritter JK, Barbier O, Tukey RH. Senekeo-Effenberger K, et al. Among authors: chen s. Drug Metab Dispos. 2007 Mar;35(3):419-27. doi: 10.1124/dmd.106.013243. Epub 2006 Dec 6. Drug Metab Dispos. 2007. PMID: 17151188
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