Northcote P - Search Results

1

Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures.

Kellogg EH, Hejab NMA, Howes S, Northcote P, Miller JH, Díaz JF, Downing KH, Nogales E. Kellogg EH, et al. Among authors: northcote p. J Mol Biol. 2017 Mar 10;429(5):633-646. doi: 10.1016/j.jmb.2017.01.001. Epub 2017 Jan 17. J Mol Biol. 2017. PMID: 28104363 Free PMC article.

2

Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species.

West LM, Northcote PT, Hood KA, Miller JH, Page MJ. West LM, et al. Among authors: northcote pt. J Nat Prod. 2000 May;63(5):707-9. doi: 10.1021/np9904511. J Nat Prod. 2000. PMID: 10843597

3

Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine.

Hood KA, West LM, Northcote PT, Berridge MV, Miller JH. Hood KA, et al. Among authors: northcote pt. Apoptosis. 2001 Jun;6(3):207-19. doi: 10.1023/a:1011340827558. Apoptosis. 2001. PMID: 11388670

4

The novel cytotoxic sponge metabolite peloruside A, structurally similar to bryostatin-1, has unique bioactivity independent of protein kinase C.

Hood KA, Bäckström BT, West LM, Northcote PT, Berridge MV, Miller JH. Hood KA, et al. Among authors: northcote pt. Anticancer Drug Des. 2001 Apr-Jun;16(2-3):155-66. Anticancer Drug Des. 2001. PMID: 11962513

5

Peloruside A, a novel antimitotic agent with paclitaxel-like microtubule- stabilizing activity.

Hood KA, West LM, Rouwé B, Northcote PT, Berridge MV, Wakefield SJ, Miller JH. Hood KA, et al. Cancer Res. 2002 Jun 15;62(12):3356-60. Cancer Res. 2002. PMID: 12067973

6

Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines.

Gaitanos TN, Buey RM, Díaz JF, Northcote PT, Teesdale-Spittle P, Andreu JM, Miller JH. Gaitanos TN, et al. Among authors: northcote pt. Cancer Res. 2004 Aug 1;64(15):5063-7. doi: 10.1158/0008-5472.CAN-04-0771. Cancer Res. 2004. PMID: 15289305

7

NMR determination of the bioactive conformation of peloruside A bound to microtubules.

Jiménez-Barbero J, Canales A, Northcote PT, Buey RM, Andreu JM, Díaz JF. Jiménez-Barbero J, et al. J Am Chem Soc. 2006 Jul 12;128(27):8757-65. doi: 10.1021/ja0580237. J Am Chem Soc. 2006. PMID: 16819869

8

Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.

Hamel E, Day BW, Miller JH, Jung MK, Northcote PT, Ghosh AK, Curran DP, Cushman M, Nicolaou KC, Paterson I, Sorensen EJ. Hamel E, et al. Among authors: northcote pt. Mol Pharmacol. 2006 Nov;70(5):1555-64. doi: 10.1124/mol.106.027847. Epub 2006 Aug 3. Mol Pharmacol. 2006. PMID: 16887932

9

Peloruside A synergizes with other microtubule stabilizing agents in cultured cancer cell lines.

Wilmes A, Bargh K, Kelly C, Northcote PT, Miller JH. Wilmes A, et al. Mol Pharm. 2007 Mar-Apr;4(2):269-80. doi: 10.1021/mp060101p. Mol Pharm. 2007. PMID: 17397239

10

Delaying the onset of experimental autoimmune encephalomyelitis with the microtubule-stabilizing compounds, paclitaxel and Peloruside A.

Crume KP, O'Sullivan D, Miller JH, Northcote PT, La Flamme AC. Crume KP, et al. Among authors: northcote pt. J Leukoc Biol. 2009 Oct;86(4):949-58. doi: 10.1189/jlb.0908541. Epub 2009 Aug 4. J Leukoc Biol. 2009. PMID: 19654226

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