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Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.
Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V. Di Pardo A, et al. Among authors: pepe g. Sci Rep. 2017 Jul 13;7(1):5280. doi: 10.1038/s41598-017-05709-y. Sci Rep. 2017. PMID: 28706199 Free PMC article.
Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease.
Di Pardo A, Castaldo S, Amico E, Pepe G, Marracino F, Capocci L, Giovannelli A, Madonna M, van Bergeijk J, Buttari F, van der Kam E, Maglione V. Di Pardo A, et al. Among authors: pepe g. Hum Mol Genet. 2018 Jul 15;27(14):2490-2501. doi: 10.1093/hmg/ddy153. Hum Mol Genet. 2018. PMID: 29688337
Author Correction: Defective Sphingosine-1-phosphate metabolism is a druggable target in Huntington's disease.
Di Pardo A, Amico E, Basit A, Armirotti A, Joshi P, Neely MD, Vuono R, Castaldo S, Digilio AF, Scalabrì F, Pepe G, Elifani F, Madonna M, Jeong SK, Park BM, D'Esposito M, Bowman AB, Barker RA, Maglione V. Di Pardo A, et al. Among authors: pepe g. Sci Rep. 2018 May 24;8(1):8266. doi: 10.1038/s41598-018-23083-1. Sci Rep. 2018. PMID: 29795393 Free PMC article.
The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum-microglia crosstalk preventing disease progression in a mouse model of Huntington's disease.
Di Pardo A, Ciaglia E, Cattaneo M, Maciag A, Montella F, Lopardo V, Ferrario A, Villa F, Madonna M, Amico E, Carrizzo A, Damato A, Pepe G, Marracino F, Auricchio A, Vecchione C, Maglione V, Puca AA. Di Pardo A, et al. Among authors: pepe g. Cell Death Dis. 2020 Jul 18;11(7):546. doi: 10.1038/s41419-020-02754-w. Cell Death Dis. 2020. PMID: 32683420 Free PMC article.
840 results