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Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.
Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. Nystoriak MA, et al. Among authors: hofmann f. Sci Signal. 2017 Jan 24;10(463):eaaf9647. doi: 10.1126/scisignal.aaf9647. Sci Signal. 2017. PMID: 28119464 Free PMC article.
Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons.
Qian H, Patriarchi T, Price JL, Matt L, Lee B, Nieves-Cintrón M, Buonarati OR, Chowdhury D, Nanou E, Nystoriak MA, Catterall WA, Poomvanicha M, Hofmann F, Navedo MF, Hell JW. Qian H, et al. Among authors: hofmann f. Sci Signal. 2017 Jan 24;10(463):eaaf9659. doi: 10.1126/scisignal.aaf9659. Sci Signal. 2017. PMID: 28119465 Free PMC article.
Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.
Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW. Patriarchi T, et al. Among authors: hofmann f. EMBO J. 2016 Jun 15;35(12):1330-45. doi: 10.15252/embj.201593409. Epub 2016 Apr 21. EMBO J. 2016. PMID: 27103070 Free PMC article.
Contribution of D1R-expressing neurons of the dorsal dentate gyrus and Cav1.2 channels in extinction of cocaine conditioned place preference.
Burgdorf CE, Bavley CC, Fischer DK, Walsh AP, Martinez-Rivera A, Hackett JE, Zallar LJ, Ireton KE, Hofmann F, Hell JW, Huganir RL, Rajadhyaksha AM. Burgdorf CE, et al. Among authors: hofmann f. Neuropsychopharmacology. 2020 Aug;45(9):1506-1517. doi: 10.1038/s41386-019-0597-z. Epub 2020 Jan 6. Neuropsychopharmacology. 2020. PMID: 31905369 Free PMC article.
Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.
Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, Bers DM, Molkentin JD. Goonasekera SA, et al. Among authors: hofmann f. J Clin Invest. 2012 Jan;122(1):280-90. doi: 10.1172/JCI58227. Epub 2011 Dec 1. J Clin Invest. 2012. PMID: 22133878 Free PMC article.
937 results