Cullis PR - Search Results

1

A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo.

Lee JB, Zhang K, Tam YY, Quick J, Tam YK, Lin PJ, Chen S, Liu Y, Nair JK, Zlatev I, Rajeev KG, Manoharan M, Rennie PS, Cullis PR. Lee JB, et al. Among authors: cullis pr. Mol Ther Nucleic Acids. 2016;5(8):e348. doi: 10.1038/mtna.2016.43. Mol Ther Nucleic Acids. 2016. PMID: 28131285 Free PMC article.

2

Encapsulation in liposomal nanoparticles enhances the immunostimulatory, adjuvant and anti-tumor activity of subcutaneously administered CpG ODN.

de Jong S, Chikh G, Sekirov L, Raney S, Semple S, Klimuk S, Yuan N, Hope M, Cullis P, Tam Y. de Jong S, et al. Cancer Immunol Immunother. 2007 Aug;56(8):1251-64. doi: 10.1007/s00262-006-0276-x. Epub 2007 Jan 23. Cancer Immunol Immunother. 2007. PMID: 17242927 Free PMC article.

3

Effects of intravenous and subcutaneous administration on the pharmacokinetics, biodistribution, cellular uptake and immunostimulatory activity of CpG ODN encapsulated in liposomal nanoparticles.

Wilson KD, Raney SG, Sekirov L, Chikh G, deJong SD, Cullis PR, Tam YK. Wilson KD, et al. Among authors: cullis pr. Int Immunopharmacol. 2007 Aug;7(8):1064-75. doi: 10.1016/j.intimp.2007.04.002. Epub 2007 May 2. Int Immunopharmacol. 2007. PMID: 17570323

4

The effect of circulation lifetime and drug-to-lipid ratio of intravenously administered lipid nanoparticles on the biodistribution and immunostimulatory activity of encapsulated CpG-ODN.

Raney SG, Wilson KD, Sekirov L, Chikh G, de Jong SD, Cullis PR, Tam YK. Raney SG, et al. Among authors: cullis pr. J Drug Target. 2008 Aug;16(7):564-77. doi: 10.1080/10611860802228756. J Drug Target. 2008. PMID: 18686126

5

The combination of stabilized plasmid lipid particles and lipid nanoparticle encapsulated CpG containing oligodeoxynucleotides as a systemic genetic vaccine.

Wilson KD, de Jong SD, Kazem M, Lall R, Hope MJ, Cullis PR, Tam YK. Wilson KD, et al. Among authors: cullis pr. J Gene Med. 2009 Jan;11(1):14-25. doi: 10.1002/jgm.1267. J Gene Med. 2009. PMID: 19003796

6

Synthetic methylated CpG ODNs are potent in vivo adjuvants when delivered in liposomal nanoparticles.

Chikh G, de Jong SD, Sekirov L, Raney SG, Kazem M, Wilson KD, Cullis PR, Dutz JP, Tam YK. Chikh G, et al. Among authors: cullis pr. Int Immunol. 2009 Jul;21(7):757-67. doi: 10.1093/intimm/dxp044. Epub 2009 Jun 5. Int Immunol. 2009. PMID: 19502586

7

Synthesis of a labeled RGD-lipid, its incorporation into liposomal nanoparticles, and their trafficking in cultured endothelial cells.

Cressman S, Dobson I, Lee JB, Tam YY, Cullis PR. Cressman S, et al. Among authors: cullis pr. Bioconjug Chem. 2009 Jul;20(7):1404-11. doi: 10.1021/bc900041f. Bioconjug Chem. 2009. PMID: 19534457

8

Rational design of cationic lipids for siRNA delivery.

Semple SC, Akinc A, Chen J, Sandhu AP, Mui BL, Cho CK, Sah DW, Stebbing D, Crosley EJ, Yaworski E, Hafez IM, Dorkin JR, Qin J, Lam K, Rajeev KG, Wong KF, Jeffs LB, Nechev L, Eisenhardt ML, Jayaraman M, Kazem M, Maier MA, Srinivasulu M, Weinstein MJ, Chen Q, Alvarez R, Barros SA, De S, Klimuk SK, Borland T, Kosovrasti V, Cantley WL, Tam YK, Manoharan M, Ciufolini MA, Tracy MA, de Fougerolles A, MacLachlan I, Cullis PR, Madden TD, Hope MJ. Semple SC, et al. Among authors: cullis pr. Nat Biotechnol. 2010 Feb;28(2):172-6. doi: 10.1038/nbt.1602. Epub 2010 Jan 17. Nat Biotechnol. 2010. PMID: 20081866

9

The immunostimulatory activity of unmethylated and methylated CpG oligodeoxynucleotide is dependent on their ability to colocalize with TLR9 in late endosomes.

de Jong SD, Basha G, Wilson KD, Kazem M, Cullis P, Jefferies W, Tam Y. de Jong SD, et al. J Immunol. 2010 Jun 1;184(11):6092-102. doi: 10.4049/jimmunol.0802442. Epub 2010 Apr 28. J Immunol. 2010. PMID: 20427776

10

Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells.

Basha G, Novobrantseva TI, Rosin N, Tam YY, Hafez IM, Wong MK, Sugo T, Ruda VM, Qin J, Klebanov B, Ciufolini M, Akinc A, Tam YK, Hope MJ, Cullis PR. Basha G, et al. Among authors: cullis pr. Mol Ther. 2011 Dec;19(12):2186-200. doi: 10.1038/mt.2011.190. Epub 2011 Oct 4. Mol Ther. 2011. PMID: 21971424 Free PMC article.

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