Pruess T - Search Results

1

Efficacy of mGlu₂ -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures.

Metcalf CS, Klein BD, Smith MD, Pruess T, Ceusters M, Lavreysen H, Pype S, Van Osselaer N, Twyman R, White HS. Metcalf CS, et al. Among authors: pruess t. Epilepsia. 2017 Mar;58(3):484-493. doi: 10.1111/epi.13659. Epub 2017 Feb 6. Epilepsia. 2017. PMID: 28166368

2

Acute treatment with minocycline, but not valproic acid, improves long-term behavioral outcomes in the Theiler's virus model of temporal lobe epilepsy.

Barker-Haliski ML, Heck TD, Dahle EJ, Vanegas F, Pruess TH, Wilcox KS, White HS. Barker-Haliski ML, et al. Among authors: pruess th. Epilepsia. 2016 Dec;57(12):1958-1967. doi: 10.1111/epi.13577. Epub 2016 Oct 14. Epilepsia. 2016. PMID: 27739576 Free PMC article.

3

Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models.

White HS, Scholl EA, Klein BD, Flynn SP, Pruess TH, Green BR, Zhang L, Bulaj G. White HS, et al. Neurotherapeutics. 2009 Apr;6(2):372-80. doi: 10.1016/j.nurt.2009.01.001. Neurotherapeutics. 2009. PMID: 19332332 Free PMC article.

4

Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions.

Otto JF, Singh NA, Dahle EJ, Leppert MF, Pappas CM, Pruess TH, Wilcox KS, White HS. Otto JF, et al. Epilepsia. 2009 Jul;50(7):1752-9. doi: 10.1111/j.1528-1167.2009.02100.x. Epub 2009 Apr 27. Epilepsia. 2009. PMID: 19453707 Free article.

5

Introduction of lipidization-cationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities.

Green BR, White KL, McDougle DR, Zhang L, Klein B, Scholl EA, Pruess TH, White HS, Bulaj G. Green BR, et al. Among authors: pruess th. J Pept Sci. 2010 Sep;16(9):486-95. doi: 10.1002/psc.1266. J Pept Sci. 2010. PMID: 20645434

6

Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs.

West PJ, Thomson K, Billingsley P, Pruess T, Rueda C, Saunders GW, Smith MD, Metcalf CS, Wilcox KS. West PJ, et al. Among authors: pruess t. Exp Neurol. 2022 Mar;349:113954. doi: 10.1016/j.expneurol.2021.113954. Epub 2021 Dec 17. Exp Neurol. 2022. PMID: 34922908 Free PMC article.

7

Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities.

Bulaj G, Green BR, Lee HK, Robertson CR, White K, Zhang L, Sochanska M, Flynn SP, Scholl EA, Pruess TH, Smith MD, White HS. Bulaj G, et al. J Med Chem. 2008 Dec 25;51(24):8038-47. doi: 10.1021/jm801088x. J Med Chem. 2008. PMID: 19053761

8

Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues.

Zhang L, Robertson CR, Green BR, Pruess TH, White HS, Bulaj G. Zhang L, et al. J Med Chem. 2009 Mar 12;52(5):1310-6. doi: 10.1021/jm801397w. J Med Chem. 2009. PMID: 19199479 Free PMC article.

9

Evaluating an etiologically relevant platform for therapy development for temporal lobe epilepsy: effects of carbamazepine and valproic acid on acute seizures and chronic behavioral comorbidities in the Theiler's murine encephalomyelitis virus mouse model.

Barker-Haliski ML, Dahle EJ, Heck TD, Pruess TH, Vanegas F, Wilcox KS, White HS. Barker-Haliski ML, et al. Among authors: pruess th. J Pharmacol Exp Ther. 2015 May;353(2):318-29. doi: 10.1124/jpet.114.222513. Epub 2015 Mar 9. J Pharmacol Exp Ther. 2015. PMID: 25755209 Free PMC article.

10

Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery.

Robertson CR, Scholl EA, Pruess TH, Green BR, White HS, Bulaj G. Robertson CR, et al. Among authors: pruess th. J Med Chem. 2010 Feb 25;53(4):1871-5. doi: 10.1021/jm9018349. J Med Chem. 2010. PMID: 20121116 Free PMC article.

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