Roy J - Search Results

1

Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models.

Kenmogne LC, Roy J, Maltais R, Rouleau M, Neveu B, Pouliot F, Poirier D. Kenmogne LC, et al. Among authors: roy j. PLoS One. 2017 Feb 9;12(2):e0171871. doi: 10.1371/journal.pone.0171871. eCollection 2017. PLoS One. 2017. PMID: 28182747 Free PMC article.

2

Chemical synthesis and biological activities of 16alpha-derivatives of 5alpha-androstane-3alpha,17beta-diol as antiandrogens.

Roy J, Breton R, Martel C, Labrie F, Poirier D. Roy J, et al. Bioorg Med Chem. 2007 Apr 15;15(8):3003-18. doi: 10.1016/j.bmc.2007.02.007. Epub 2007 Feb 13. Bioorg Med Chem. 2007. PMID: 17336533

3

2beta-(N-substituted piperazino)-5alpha-androstane-3alpha,17beta-diols: parallel solid-phase synthesis and antiproliferative activity on human leukemia HL-60 cells.

Roy J, DeRoy P, Poirier D. Roy J, et al. J Comb Chem. 2007 May-Jun;9(3):347-58. doi: 10.1021/cc060098z. Epub 2007 Apr 19. J Comb Chem. 2007. PMID: 17441773

4

Chemical synthesis of 2beta-amino-5alpha-androstane-3alpha,17beta-diol N-derivatives and their antiproliferative effect on HL-60 human leukemia cells.

Thibeault D, Roy J, DeRoy P, Poirier D. Thibeault D, et al. Among authors: roy j. Bioorg Med Chem. 2008 May 1;16(9):5062-77. doi: 10.1016/j.bmc.2008.03.031. Epub 2008 Mar 14. Bioorg Med Chem. 2008. PMID: 18375126

5

In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: chemical synthesis and structure - activity relationships.

Gulea A, Poirier D, Roy J, Stavila V, Bulimestru I, Tapcov V, Birca M, Popovschi L. Gulea A, et al. Among authors: roy j. J Enzyme Inhib Med Chem. 2008 Dec;23(6):806-18. doi: 10.1080/14756360701743002. J Enzyme Inhib Med Chem. 2008. PMID: 18618364 Free article.

6

Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes.

Roy J, Maltais R, Jegham H, Poirier D. Roy J, et al. Mol Divers. 2011 May;15(2):317-39. doi: 10.1007/s11030-010-9273-2. Epub 2010 Sep 9. Mol Divers. 2011. PMID: 20827507

7

A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells.

Jegham H, Roy J, Maltais R, Desnoyers S, Poirier D. Jegham H, et al. Among authors: roy j. Invest New Drugs. 2012 Feb;30(1):176-85. doi: 10.1007/s10637-010-9548-6. Epub 2010 Oct 2. Invest New Drugs. 2012. PMID: 20890632

8

Impact of estradiol structural modifications (18-methyl and/or 17-hydroxy inversion of configuration) on the in vitro and in vivo estrogenic activity.

Ayan D, Roy J, Maltais R, Poirier D. Ayan D, et al. Among authors: roy j. J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):324-30. doi: 10.1016/j.jsbmb.2011.07.009. Epub 2011 Aug 2. J Steroid Biochem Mol Biol. 2011. PMID: 21827856

9

Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines.

Jegham H, Maltais R, Roy J, Doillon C, Poirier D. Jegham H, et al. Among authors: roy j. Anticancer Drugs. 2012 Sep;23(8):803-14. doi: 10.1097/CAD.0b013e328351aa8c. Anticancer Drugs. 2012. PMID: 22361842

10

Solid-phase chemical synthesis and in vitro biological evaluation of novel 2β-piperazino-(20R)-5α-pregnane-3α,20-diol N-derivatives as anti-leukemic agents.

Jegham H, Maltais R, Dufour P, Roy J, Poirier D. Jegham H, et al. Among authors: roy j. Steroids. 2012 Nov;77(13):1403-18. doi: 10.1016/j.steroids.2012.07.012. Epub 2012 Aug 14. Steroids. 2012. PMID: 22910290

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