Sello JK - Search Results

1

Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.

Totaro KA, Barthelme D, Simpson PT, Jiang X, Lin G, Nathan CF, Sauer RT, Sello JK. Totaro KA, et al. Among authors: sello jk. ACS Infect Dis. 2017 Feb 10;3(2):176-181. doi: 10.1021/acsinfecdis.6b00172. Epub 2016 Dec 5. ACS Infect Dis. 2017. PMID: 28183185 Free PMC article.

2

Use of a multicomponent reaction for chemoselective derivatization of multiple classes of metabolites.

Totaro KA, Okandeji BO, Sello JK. Totaro KA, et al. Among authors: sello jk. Chembiochem. 2012 May 7;13(7):987-91. doi: 10.1002/cbic.201200035. Epub 2012 Apr 13. Chembiochem. 2012. PMID: 22505051

3

Antibacterial activity of and resistance to small molecule inhibitors of the ClpP peptidase.

Compton CL, Schmitz KR, Sauer RT, Sello JK. Compton CL, et al. Among authors: sello jk. ACS Chem Biol. 2013 Dec 20;8(12):2669-77. doi: 10.1021/cb400577b. Epub 2013 Oct 4. ACS Chem Biol. 2013. PMID: 24047344 Free PMC article.

4

Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity.

Carney DW, Schmitz KR, Truong JV, Sauer RT, Sello JK. Carney DW, et al. Among authors: sello jk. J Am Chem Soc. 2014 Feb 5;136(5):1922-9. doi: 10.1021/ja410385c. Epub 2014 Jan 24. J Am Chem Soc. 2014. PMID: 24422534 Free PMC article.

5

Efficient and regiospecific syntheses of peptides with piperazic and dehydropiperazic acids via a multicomponent reaction.

Handy EL, Totaro KA, Lin CP, Sello JK. Handy EL, et al. Among authors: sello jk. Org Lett. 2014 Jul 3;16(13):3488-91. doi: 10.1021/ol501425b. Epub 2014 Jun 17. Org Lett. 2014. PMID: 24937740

6

A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity.

Carney DW, Compton CL, Schmitz KR, Stevens JP, Sauer RT, Sello JK. Carney DW, et al. Among authors: sello jk. Chembiochem. 2014 Oct 13;15(15):2216-20. doi: 10.1002/cbic.201402358. Epub 2014 Sep 11. Chembiochem. 2014. PMID: 25212124 Free PMC article.

7

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery.

Schmitz KR, Carney DW, Sello JK, Sauer RT. Schmitz KR, et al. Among authors: sello jk. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):E4587-95. doi: 10.1073/pnas.1417120111. Epub 2014 Sep 29. Proc Natl Acad Sci U S A. 2014. PMID: 25267638 Free PMC article.

8

Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase.

Carney DW, Schmitz KR, Scruse AC, Sauer RT, Sello JK. Carney DW, et al. Among authors: sello jk. Chembiochem. 2015 Sep 7;16(13):1875-1879. doi: 10.1002/cbic.201500234. Epub 2015 Jul 27. Chembiochem. 2015. PMID: 26147653 Free PMC article.

9

Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines.

Totaro KA, Barthelme D, Simpson PT, Sauer RT, Sello JK. Totaro KA, et al. Among authors: sello jk. Bioorg Med Chem. 2015 Sep 15;23(18):6218-22. doi: 10.1016/j.bmc.2015.07.041. Epub 2015 Jul 26. Bioorg Med Chem. 2015. PMID: 26296913 Free PMC article.

10

Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle.

Amor AJ, Schmitz KR, Sello JK, Baker TA, Sauer RT. Amor AJ, et al. Among authors: sello jk. ACS Chem Biol. 2016 Jun 17;11(6):1552-1560. doi: 10.1021/acschembio.6b00083. Epub 2016 Mar 30. ACS Chem Biol. 2016. PMID: 27003103 Free PMC article.

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