Ferreira RS - Search Results

1

Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification.

Braga SF, Martins LC, da Silva EB, Sales Júnior PA, Murta SM, Romanha AJ, Soh WT, Brandstetter H, Ferreira RS, de Oliveira RB. Braga SF, et al. Among authors: ferreira rs. Bioorg Med Chem. 2017 Mar 15;25(6):1889-1900. doi: 10.1016/j.bmc.2017.02.009. Epub 2017 Feb 9. Bioorg Med Chem. 2017. PMID: 28215783

2

Divergent modes of enzyme inhibition in a homologous structure-activity series.

Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR. Ferreira RS, et al. J Med Chem. 2009 Aug 27;52(16):5005-8. doi: 10.1021/jm9009229. J Med Chem. 2009. PMID: 19637873 Free PMC article.

3

Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.

Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Bryant C, et al. Among authors: ferreira rs. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. doi: 10.1016/j.bmcl.2009.08.098. Epub 2009 Sep 3. Bioorg Med Chem Lett. 2009. PMID: 19773167 Free PMC article.

4

Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.

Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, Maloney DJ. Mott BT, et al. Among authors: ferreira rs. J Med Chem. 2010 Jan 14;53(1):52-60. doi: 10.1021/jm901069a. J Med Chem. 2010. PMID: 19908842 Free PMC article.

5

Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors.

Ferreira RS, Simeonov A, Jadhav A, Eidam O, Mott BT, Keiser MJ, McKerrow JH, Maloney DJ, Irwin JJ, Shoichet BK. Ferreira RS, et al. J Med Chem. 2010 Jul 8;53(13):4891-905. doi: 10.1021/jm100488w. J Med Chem. 2010. PMID: 20540517 Free PMC article.

6

Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents.

Hernandes MZ, Rabello MM, Leite AC, Cardoso MV, Moreira DR, Brondani DJ, Simone CA, Reis LC, Souza MA, Pereira VR, Ferreira RS, McKerrow JH. Hernandes MZ, et al. Among authors: ferreira rs. Bioorg Med Chem. 2010 Nov 15;18(22):7826-35. doi: 10.1016/j.bmc.2010.09.056. Epub 2010 Sep 29. Bioorg Med Chem. 2010. PMID: 20961766 Free article.

7

Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice.

dos Santos Filho JM, Moreira DR, de Simone CA, Ferreira RS, McKerrow JH, Meira CS, Guimarães ET, Soares MB. dos Santos Filho JM, et al. Among authors: ferreira rs. Bioorg Med Chem. 2012 Nov 1;20(21):6423-33. doi: 10.1016/j.bmc.2012.08.047. Epub 2012 Aug 31. Bioorg Med Chem. 2012. PMID: 23006639 Free article.

8

Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.

Moreira DR, Costa SP, Hernandes MZ, Rabello MM, de Oliveira Filho GB, de Melo CM, da Rocha LF, de Simone CA, Ferreira RS, Fradico JR, Meira CS, Guimarães ET, Srivastava RM, Pereira VR, Soares MB, Leite AC. Moreira DR, et al. Among authors: ferreira rs. J Med Chem. 2012 Dec 27;55(24):10918-36. doi: 10.1021/jm301518v. Epub 2012 Dec 7. J Med Chem. 2012. PMID: 23167554

9

Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones.

Braga SF, Alves ÉV, Ferreira RS, Fradico JR, Lage PS, Duarte MC, Ribeiro TG, Júnior PA, Romanha AJ, Tonini ML, Steindel M, Coelho EF, de Oliveira RB. Braga SF, et al. Among authors: ferreira rs. Eur J Med Chem. 2014 Jan;71:282-9. doi: 10.1016/j.ejmech.2013.11.011. Epub 2013 Nov 16. Eur J Med Chem. 2014. PMID: 24321832

10

Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents.

Ferreira RS, Dessoy MA, Pauli I, Souza ML, Krogh R, Sales AI, Oliva G, Dias LC, Andricopulo AD. Ferreira RS, et al. J Med Chem. 2014 Mar 27;57(6):2380-92. doi: 10.1021/jm401709b. Epub 2014 Mar 3. J Med Chem. 2014. PMID: 24533839 Free article.

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