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Page 1
GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis.
Géraud C, Koch PS, Zierow J, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin HG, Schledzewski K, Goerdt S. Géraud C, et al. Among authors: karppinen sm. J Clin Invest. 2017 Mar 1;127(3):1099-1114. doi: 10.1172/JCI90086. Epub 2017 Feb 20. J Clin Invest. 2017. PMID: 28218627 Free PMC article.
Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models.
Devarajan R, Izzi V, Peltoketo H, Rask G, Kauppila S, Väisänen MR, Ruotsalainen H, Martínez-Nieto G, Karppinen SM, Väisänen T, Kaur I, Koivunen J, Sasaki T, Winqvist R, Manninen A, Wärnberg F, Sund M, Pihlajaniemi T, Heljasvaara R. Devarajan R, et al. Among authors: karppinen sm. J Clin Invest. 2023 Sep 15;133(18):e159181. doi: 10.1172/JCI159181. J Clin Invest. 2023. PMID: 37498672 Free PMC article.
Collagen XV, a multifaceted multiplexin present across tissues and species.
Bretaud S, Guillon E, Karppinen SM, Pihlajaniemi T, Ruggiero F. Bretaud S, et al. Among authors: karppinen sm. Matrix Biol Plus. 2020 Jan 15;6-7:100023. doi: 10.1016/j.mbplus.2020.100023. eCollection 2020 May. Matrix Biol Plus. 2020. PMID: 33543021 Free PMC article.
Collagens XV and XVIII show different expression and localisation in cutaneous squamous cell carcinoma: type XV appears in tumor stroma, while XVIII becomes upregulated in tumor cells and lost from microvessels.
Karppinen SM, Honkanen HK, Heljasvaara R, Riihilä P, Autio-Harmainen H, Sormunen R, Harjunen V, Väisänen MR, Väisänen T, Hurskainen T, Tasanen K, Kähäri VM, Pihlajaniemi T. Karppinen SM, et al. Exp Dermatol. 2016 May;25(5):348-54. doi: 10.1111/exd.12913. Exp Dermatol. 2016. PMID: 26660139
Deletion of Col15a1 Modulates the Tumour Extracellular Matrix and Leads to Increased Tumour Growth in the MMTV-PyMT Mouse Mammary Carcinoma Model.
Martínez-Nieto G, Heljasvaara R, Heikkinen A, Kaski HK, Devarajan R, Rinne O, Henriksson C, Thomson E, von Hertzen C, Miinalainen I, Ruotsalainen H, Pihlajaniemi T, Karppinen SM. Martínez-Nieto G, et al. Among authors: karppinen sm. Int J Mol Sci. 2021 Sep 15;22(18):9978. doi: 10.3390/ijms22189978. Int J Mol Sci. 2021. PMID: 34576139 Free PMC article.
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