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Page 1
Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: a first round of lead optimization.
La Pietra V, Marinelli L, Cosconati S, Di Leva FS, Nuti E, Santamaria S, Pugliesi I, Morelli M, Casalini F, Rossello A, La Motta C, Taliani S, Visse R, Nagase H, da Settimo F, Novellino E. La Pietra V, et al. Among authors: di leva fs. Eur J Med Chem. 2012 Jan;47(1):143-52. doi: 10.1016/j.ejmech.2011.10.035. Epub 2011 Oct 25. Eur J Med Chem. 2012. PMID: 22088955
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.
Costi R, Métifiot M, Chung S, Cuzzucoli Crucitti G, Maddali K, Pescatori L, Messore A, Madia VN, Pupo G, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Marinelli L, Novellino E, Le Grice SF, Corona A, Pommier Y, Marchand C, Di Santo R. Costi R, et al. Among authors: di leva fs, di santo r. J Med Chem. 2014 Apr 24;57(8):3223-34. doi: 10.1021/jm5001503. Epub 2014 Apr 11. J Med Chem. 2014. PMID: 24684270 Free PMC article.
Mechanistic insight into ligand binding to G-quadruplex DNA.
Di Leva FS, Novellino E, Cavalli A, Parrinello M, Limongelli V. Di Leva FS, et al. Nucleic Acids Res. 2014 May;42(9):5447-55. doi: 10.1093/nar/gku247. Epub 2014 Apr 21. Nucleic Acids Res. 2014. PMID: 24753420 Free PMC article.
Identification of highly conserved residues involved in inhibition of HIV-1 RNase H function by Diketo acid derivatives.
Corona A, Di Leva FS, Thierry S, Pescatori L, Cuzzucoli Crucitti G, Subra F, Delelis O, Esposito F, Rigogliuso G, Costi R, Cosconati S, Novellino E, Di Santo R, Tramontano E. Corona A, et al. Among authors: di leva fs, di santo r. Antimicrob Agents Chemother. 2014 Oct;58(10):6101-10. doi: 10.1128/AAC.03605-14. Epub 2014 Aug 4. Antimicrob Agents Chemother. 2014. PMID: 25092689 Free PMC article.
Modification on ursodeoxycholic acid (UDCA) scaffold. discovery of bile acid derivatives as selective agonists of cell-surface G-protein coupled bile acid receptor 1 (GP-BAR1).
Sepe V, Renga B, Festa C, D'Amore C, Masullo D, Cipriani S, Di Leva FS, Monti MC, Novellino E, Limongelli V, Zampella A, Fiorucci S. Sepe V, et al. Among authors: di leva fs. J Med Chem. 2014 Sep 25;57(18):7687-701. doi: 10.1021/jm500889f. Epub 2014 Sep 7. J Med Chem. 2014. PMID: 25162837
Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.
Cuzzucoli Crucitti G, Pescatori L, Messore A, Madia VN, Pupo G, Saccoliti F, Scipione L, Tortorella S, Di Leva FS, Cosconati S, Novellino E, Debyser Z, Christ F, Costi R, Di Santo R. Cuzzucoli Crucitti G, et al. Among authors: di leva fs, di santo r. Eur J Med Chem. 2015 Aug 28;101:288-94. doi: 10.1016/j.ejmech.2015.06.036. Epub 2015 Jun 22. Eur J Med Chem. 2015. PMID: 26150289
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