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Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
Moniot S, Forgione M, Lucidi A, Hailu GS, Nebbioso A, Carafa V, Baratta F, Altucci L, Giacché N, Passeri D, Pellicciari R, Mai A, Steegborn C, Rotili D. Moniot S, et al. Among authors: lucidi a. J Med Chem. 2017 Mar 23;60(6):2344-2360. doi: 10.1021/acs.jmedchem.6b01609. Epub 2017 Mar 14. J Med Chem. 2017. PMID: 28240897
Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3 H)-ones.
Nawrozkij MB, Forgione M, Yablokov AS, Lucidi A, Tomaselli D, Patsilinakos A, Panella C, Hailu GS, Kirillov IA, Badia R, Riveira-Muñoz E, Crespan E, Armijos Rivera JI, Cirilli R, Ragno R, Esté JA, Maga G, Mai A, Rotili D. Nawrozkij MB, et al. Among authors: lucidi a. J Med Chem. 2019 Jan 24;62(2):604-621. doi: 10.1021/acs.jmedchem.8b01238. Epub 2018 Dec 20. J Med Chem. 2019. PMID: 30525601
Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models.
Menna M, Fiorentino F, Marrocco B, Lucidi A, Tomassi S, Cilli D, Romanenghi M, Cassandri M, Pomella S, Pezzella M, Del Bufalo D, Zeya Ansari MS, Tomašević N, Mladenović M, Viviano M, Sbardella G, Rota R, Trisciuoglio D, Minucci S, Mattevi A, Rotili D, Mai A. Menna M, et al. Among authors: lucidi a. Eur J Med Chem. 2022 Jul 5;237:114410. doi: 10.1016/j.ejmech.2022.114410. Epub 2022 Apr 27. Eur J Med Chem. 2022. PMID: 35525212
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features.
Speranzini V, Rotili D, Ciossani G, Pilotto S, Marrocco B, Forgione M, Lucidi A, Forneris F, Mehdipour P, Velankar S, Mai A, Mattevi A. Speranzini V, et al. Among authors: lucidi a. Sci Adv. 2016 Sep 9;2(9):e1601017. doi: 10.1126/sciadv.1601017. eCollection 2016 Sep. Sci Adv. 2016. PMID: 27626075 Free PMC article.
Identification of novel quinazoline derivatives as potent antiplasmodial agents.
Bouchut A, Rotili D, Pierrot C, Valente S, Lafitte S, Schultz J, Hoglund U, Mazzone R, Lucidi A, Fabrizi G, Pechalrieu D, Arimondo PB, Skinner-Adams TS, Chua MJ, Andrews KT, Mai A, Khalife J. Bouchut A, et al. Among authors: lucidi a. Eur J Med Chem. 2019 Jan 1;161:277-291. doi: 10.1016/j.ejmech.2018.10.041. Epub 2018 Oct 17. Eur J Med Chem. 2019. PMID: 30366254
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.
Iachettini S, Trisciuoglio D, Rotili D, Lucidi A, Salvati E, Zizza P, Di Leo L, Del Bufalo D, Ciriolo MR, Leonetti C, Steegborn C, Mai A, Rizzo A, Biroccio A. Iachettini S, et al. Among authors: lucidi a. Cell Death Dis. 2018 Sep 24;9(10):996. doi: 10.1038/s41419-018-1065-0. Cell Death Dis. 2018. PMID: 30250025 Free PMC article.
Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis.
Di Paolo V, Fulci C, Rotili D, Sciarretta F, Lucidi A, Morozzo Della Rocca B, De Luca A, Rosato A, Quintieri L, Caccuri AM. Di Paolo V, et al. Among authors: lucidi a. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1131-1139. doi: 10.1080/14756366.2019.1617287. J Enzyme Inhib Med Chem. 2019. PMID: 31169043 Free PMC article.
66 results