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Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure-Activity Relationship, X-ray Crystal Structure, and Anticancer Activity.
Moniot S, Forgione M, Lucidi A, Hailu GS, Nebbioso A, Carafa V, Baratta F, Altucci L, Giacché N, Passeri D, Pellicciari R, Mai A, Steegborn C, Rotili D. Moniot S, et al. Among authors: steegborn c. J Med Chem. 2017 Mar 23;60(6):2344-2360. doi: 10.1021/acs.jmedchem.6b01609. Epub 2017 Mar 14. J Med Chem. 2017. PMID: 28240897
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.
Balbach M, Rossetti T, Ferreira J, Ghanem L, Ritagliati C, Myers RW, Huggins DJ, Steegborn C, Miranda IC, Meinke PT, Buck J, Levin LR. Balbach M, et al. Among authors: steegborn c. Nat Commun. 2023 Feb 14;14(1):637. doi: 10.1038/s41467-023-36119-6. Nat Commun. 2023. PMID: 36788210 Free PMC article.
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
Sun S, Fushimi M, Rossetti T, Kaur N, Ferreira J, Miller M, Quast J, van den Heuvel J, Steegborn C, Levin LR, Buck J, Myers RW, Kargman S, Liverton N, Meinke PT, Huggins DJ. Sun S, et al. Among authors: steegborn c. J Chem Inf Model. 2023 May 8;63(9):2828-2841. doi: 10.1021/acs.jcim.2c01577. Epub 2023 Apr 15. J Chem Inf Model. 2023. PMID: 37060320
Structure-based development of novel adenylyl cyclase inhibitors.
Schlicker C, Rauch A, Hess KC, Kachholz B, Levin LR, Buck J, Steegborn C. Schlicker C, et al. Among authors: steegborn c. J Med Chem. 2008 Aug 14;51(15):4456-64. doi: 10.1021/jm800481q. Epub 2008 Jul 17. J Med Chem. 2008. PMID: 18630896 Free PMC article.
Structure-based development of novel sirtuin inhibitors.
Schlicker C, Boanca G, Lakshminarasimhan M, Steegborn C. Schlicker C, et al. Among authors: steegborn c. Aging (Albany NY). 2011 Sep;3(9):852-72. doi: 10.18632/aging.100388. Aging (Albany NY). 2011. PMID: 21937767 Free PMC article.
A molecular mechanism for direct sirtuin activation by resveratrol.
Gertz M, Nguyen GT, Fischer F, Suenkel B, Schlicker C, Fränzel B, Tomaschewski J, Aladini F, Becker C, Wolters D, Steegborn C. Gertz M, et al. Among authors: steegborn c. PLoS One. 2012;7(11):e49761. doi: 10.1371/journal.pone.0049761. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185430 Free PMC article.
134 results