de Witte WE - Search Results

1

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy.

Bot I, Ortiz Zacarías NV, de Witte WE, de Vries H, van Santbrink PJ, van der Velden D, Kröner MJ, van der Berg DJ, Stamos D, de Lange EC, Kuiper J, IJzerman AP, Heitman LH. Bot I, et al. Among authors: de witte we, de vries h, de lange ec. Sci Rep. 2017 Mar 3;7(1):52. doi: 10.1038/s41598-017-00104-z. Sci Rep. 2017. PMID: 28246398 Free PMC article.

2

Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.

de Witte WE, Wong YC, Nederpelt I, Heitman LH, Danhof M, van der Graaf PH, Gilissen RA, de Lange EC. de Witte WE, et al. Among authors: de lange ec. Expert Opin Drug Discov. 2016;11(1):45-63. doi: 10.1517/17460441.2016.1100163. Epub 2015 Oct 20. Expert Opin Drug Discov. 2016. PMID: 26484747 Review.

3

In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant.

de Witte WEA, Danhof M, van der Graaf PH, de Lange ECM. de Witte WEA, et al. Trends Pharmacol Sci. 2016 Oct;37(10):831-842. doi: 10.1016/j.tips.2016.06.008. Epub 2016 Jul 6. Trends Pharmacol Sci. 2016. PMID: 27394919 Review.

4

Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics.

de Lange ECM, van den Brink W, Yamamoto Y, de Witte WEA, Wong YC. de Lange ECM, et al. Among authors: de witte wea. Expert Opin Drug Discov. 2017 Dec;12(12):1207-1218. doi: 10.1080/17460441.2017.1380623. Epub 2017 Sep 21. Expert Opin Drug Discov. 2017. PMID: 28933618 Free article. Review.

5

Target and Tissue Selectivity Prediction by Integrated Mechanistic Pharmacokinetic-Target Binding and Quantitative Structure Activity Modeling.

Vlot AHC, de Witte WEA, Danhof M, van der Graaf PH, van Westen GJP, de Lange ECM. Vlot AHC, et al. Among authors: de witte wea. AAPS J. 2017 Dec 4;20(1):11. doi: 10.1208/s12248-017-0172-7. AAPS J. 2017. PMID: 29204742

6

Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.

de Witte WEA, Rottschäfer V, Danhof M, van der Graaf PH, Peletier LA, de Lange ECM. de Witte WEA, et al. J Pharmacokinet Pharmacodyn. 2018 Aug;45(4):621-635. doi: 10.1007/s10928-018-9593-x. Epub 2018 May 18. J Pharmacokinet Pharmacodyn. 2018. PMID: 29777407 Free PMC article.

7

In vitro and in silico analysis of the effects of D₂ receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations.

de Witte WEA, Versfelt JW, Kuzikov M, Rolland S, Georgi V, Gribbon P, Gul S, Huntjens D, van der Graaf PH, Danhof M, Fernández-Montalván A, Witt G, de Lange ECM. de Witte WEA, et al. Br J Pharmacol. 2018 Nov;175(21):4121-4136. doi: 10.1111/bph.14456. Epub 2018 Sep 21. Br J Pharmacol. 2018. PMID: 30051456 Free PMC article.

8

Correction to: Modelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment models.

de Witte WEA, Rottschäfer V, Danhof M, van der Graaf PH, Peletier LA, de Lange ECM. de Witte WEA, et al. J Pharmacokinet Pharmacodyn. 2018 Oct;45(5):763. doi: 10.1007/s10928-018-9604-y. J Pharmacokinet Pharmacodyn. 2018. PMID: 30171443 Free PMC article.

9

The implications of target saturation for the use of drug-target residence time.

de Witte WEA, Danhof M, van der Graaf PH, de Lange ECM. de Witte WEA, et al. Nat Rev Drug Discov. 2018 Dec 28;18(1):82-84. doi: 10.1038/nrd.2018.234. Nat Rev Drug Discov. 2018. PMID: 30591716 No abstract available.

10

Local depletion of large molecule drugs due to target binding in tissue interstitial space.

Zasedateleva T, Schaller S, de Lange ECM, de Witte WEA. Zasedateleva T, et al. Among authors: de witte wea. CPT Pharmacometrics Syst Pharmacol. 2024 Dec;13(12):2068-2086. doi: 10.1002/psp4.13262. Epub 2024 Nov 12. CPT Pharmacometrics Syst Pharmacol. 2024. PMID: 39530200 Free PMC article. Review.

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