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Page 1
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.
Ferry L, Fournier A, Tsusaka T, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y, Defossez PA. Ferry L, et al. Among authors: arita k. Mol Cell. 2017 Aug 17;67(4):550-565.e5. doi: 10.1016/j.molcel.2017.07.012. Epub 2017 Aug 10. Mol Cell. 2017. PMID: 28803780 Free article.
Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance.
Ishiyama S, Nishiyama A, Saeki Y, Moritsugu K, Morimoto D, Yamaguchi L, Arai N, Matsumura R, Kawakami T, Mishima Y, Hojo H, Shimamura S, Ishikawa F, Tajima S, Tanaka K, Ariyoshi M, Shirakawa M, Ikeguchi M, Kidera A, Suetake I, Arita K, Nakanishi M. Ishiyama S, et al. Among authors: arita k. Mol Cell. 2017 Oct 19;68(2):350-360.e7. doi: 10.1016/j.molcel.2017.09.037. Mol Cell. 2017. PMID: 29053958 Free article.
Enhanced processivity of Dnmt1 by monoubiquitinated histone H3.
Mishima Y, Brueckner L, Takahashi S, Kawakami T, Otani J, Shinohara A, Takeshita K, Garvilles RG, Watanabe M, Sakai N, Takeshima H, Nachtegael C, Nishiyama A, Nakanishi M, Arita K, Nakashima K, Hojo H, Suetake I. Mishima Y, et al. Among authors: arita k. Genes Cells. 2020 Jan;25(1):22-32. doi: 10.1111/gtc.12732. Epub 2019 Dec 3. Genes Cells. 2020. PMID: 31680384 Free article.
Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation.
Nishiyama A, Mulholland CB, Bultmann S, Kori S, Endo A, Saeki Y, Qin W, Trummer C, Chiba Y, Yokoyama H, Kumamoto S, Kawakami T, Hojo H, Nagae G, Aburatani H, Tanaka K, Arita K, Leonhardt H, Nakanishi M. Nishiyama A, et al. Among authors: arita k. Nat Commun. 2020 Mar 6;11(1):1222. doi: 10.1038/s41467-020-15006-4. Nat Commun. 2020. PMID: 32144273 Free PMC article.
Structure-based screening combined with computational and biochemical analyses identified the inhibitor targeting the binding of DNA Ligase 1 to UHRF1.
Kori S, Shibahashi Y, Ekimoto T, Nishiyama A, Yoshimi S, Yamaguchi K, Nagatoishi S, Ohta M, Tsumoto K, Nakanishi M, Defossez PA, Ikeguchi M, Arita K. Kori S, et al. Among authors: arita k. Bioorg Med Chem. 2021 Dec 15;52:116500. doi: 10.1016/j.bmc.2021.116500. Epub 2021 Nov 10. Bioorg Med Chem. 2021. PMID: 34801826
Structural basis for activation of DNMT1.
Kikuchi A, Onoda H, Yamaguchi K, Kori S, Matsuzawa S, Chiba Y, Tanimoto S, Yoshimi S, Sato H, Yamagata A, Shirouzu M, Adachi N, Sharif J, Koseki H, Nishiyama A, Nakanishi M, Defossez PA, Arita K. Kikuchi A, et al. Among authors: arita k. Nat Commun. 2022 Nov 21;13(1):7130. doi: 10.1038/s41467-022-34779-4. Nat Commun. 2022. PMID: 36414620 Free PMC article.
Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger.
Hata K, Kobayashi N, Sugimura K, Qin W, Haxholli D, Chiba Y, Yoshimi S, Hayashi G, Onoda H, Ikegami T, Mulholland CB, Nishiyama A, Nakanishi M, Leonhardt H, Konuma T, Arita K. Hata K, et al. Among authors: arita k. Nucleic Acids Res. 2022 Nov 28;50(21):12527-12542. doi: 10.1093/nar/gkac1082. Nucleic Acids Res. 2022. PMID: 36420895 Free PMC article.
710 results