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PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis.
Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Muñoz-Garcia A, Brash AR, Ikeda K, Arita M, Akiyama M, Murakami M. Hirabayashi T, et al. Among authors: brash ar. Nat Commun. 2017 Mar 1;8:14609. doi: 10.1038/ncomms14609. Nat Commun. 2017. PMID: 28248300 Free PMC article.
SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation.
Takeichi T, Hirabayashi T, Miyasaka Y, Kawamoto A, Okuno Y, Taguchi S, Tanahashi K, Murase C, Takama H, Tanaka K, Boeglin WE, Calcutt MW, Watanabe D, Kono M, Muro Y, Ishikawa J, Ohno T, Brash AR, Akiyama M. Takeichi T, et al. Among authors: brash ar. J Clin Invest. 2020 Feb 3;130(2):890-903. doi: 10.1172/JCI130675. J Clin Invest. 2020. PMID: 31671075 Free PMC article.
The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function: IMPLICATION OF AN EPOXIDE HYDROLASE IN THE TRANSFORMATIONS OF LINOLEATE.
Chiba T, Thomas CP, Calcutt MW, Boeglin WE, O'Donnell VB, Brash AR. Chiba T, et al. Among authors: brash ar. J Biol Chem. 2016 Jul 8;291(28):14540-54. doi: 10.1074/jbc.M115.711267. Epub 2016 May 5. J Biol Chem. 2016. PMID: 27151221 Free PMC article.
The hepoxilin connection in the epidermis.
Brash AR, Yu Z, Boeglin WE, Schneider C. Brash AR, et al. FEBS J. 2007 Jul;274(14):3494-3502. doi: 10.1111/j.1742-4658.2007.05909.x. Epub 2007 Jul 2. FEBS J. 2007. PMID: 17608720 Free article. Review.
243 results