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A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Mutations, TNBC Subtype, AR Status, and Ki67.
Jovanović B, Mayer IA, Mayer EL, Abramson VG, Bardia A, Sanders ME, Kuba MG, Estrada MV, Beeler JS, Shaver TM, Johnson KC, Sanchez V, Rosenbluth JM, Dillon PM, Forero-Torres A, Chang JC, Meszoely IM, Grau AM, Lehmann BD, Shyr Y, Sheng Q, Chen SC, Arteaga CL, Pietenpol JA. Jovanović B, et al. Among authors: pietenpol ja. Clin Cancer Res. 2017 Aug 1;23(15):4035-4045. doi: 10.1158/1078-0432.CCR-16-3055. Epub 2017 Mar 7. Clin Cancer Res. 2017. PMID: 28270498 Free PMC article. Clinical Trial.
Treatment with farnesyl-protein transferase inhibitor induces regression of mammary tumors in transforming growth factor (TGF) alpha and TGF alpha/neu transgenic mice by inhibition of mitogenic activity and induction of apoptosis.
Nørgaard P, Law B, Joseph H, Page DL, Shyr Y, Mays D, Pietenpol JA, Kohl NE, Oliff A, Coffey RJ Jr, Poulsen HS, Moses HL. Nørgaard P, et al. Among authors: pietenpol ja. Clin Cancer Res. 1999 Jan;5(1):35-42. Clin Cancer Res. 1999. PMID: 9918200
Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer.
Chakravarthy AB, Kelley MC, McLaren B, Truica CI, Billheimer D, Mayer IA, Grau AM, Johnson DH, Simpson JF, Beauchamp RD, Jones C, Pietenpol JA. Chakravarthy AB, et al. Among authors: pietenpol ja. Clin Cancer Res. 2006 Mar 1;12(5):1570-6. doi: 10.1158/1078-0432.CCR-05-2304. Clin Cancer Res. 2006. PMID: 16533783
A gene signature-based approach identifies mTOR as a regulator of p73.
Rosenbluth JM, Mays DJ, Pino MF, Tang LJ, Pietenpol JA. Rosenbluth JM, et al. Among authors: pietenpol ja. Mol Cell Biol. 2008 Oct;28(19):5951-64. doi: 10.1128/MCB.00305-08. Epub 2008 Aug 4. Mol Cell Biol. 2008. PMID: 18678646 Free PMC article.
147 results