Irie T - Search Results

1

Discovery of novel furanone derivatives as potent Cdc7 kinase inhibitors.

Irie T, Asami T, Sawa A, Uno Y, Hanada M, Taniyama C, Funakoshi Y, Masai H, Sawa M. Irie T, et al. Eur J Med Chem. 2017 Apr 21;130:406-418. doi: 10.1016/j.ejmech.2017.02.030. Epub 2017 Feb 17. Eur J Med Chem. 2017. PMID: 28279847

2

Design and combinatorial synthesis of a novel kinase-focused library using click chemistry-based fragment assembly.

Irie T, Fujii I, Sawa M. Irie T, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):591-6. doi: 10.1016/j.bmcl.2011.10.076. Epub 2011 Oct 30. Bioorg Med Chem Lett. 2012. PMID: 22104147

3

Design and synthesis of novel pyrimidine analogs as highly selective, non-covalent BTK inhibitors.

Kawahata W, Asami T, Irie T, Sawa M. Kawahata W, et al. Among authors: irie t. Bioorg Med Chem Lett. 2018 Jan 15;28(2):145-151. doi: 10.1016/j.bmcl.2017.11.037. Epub 2017 Nov 24. Bioorg Med Chem Lett. 2018. PMID: 29198867

4

7-Azaindole: A Versatile Scaffold for Developing Kinase Inhibitors.

Irie T, Sawa M. Irie T, et al. Chem Pharm Bull (Tokyo). 2018;66(1):29-36. doi: 10.1248/cpb.c17-00380. Chem Pharm Bull (Tokyo). 2018. PMID: 29311509 Free article. Review.

5

Design and Synthesis of Novel Amino-triazine Analogues as Selective Bruton's Tyrosine Kinase Inhibitors for Treatment of Rheumatoid Arthritis.

Kawahata W, Asami T, Kiyoi T, Irie T, Taniguchi H, Asamitsu Y, Inoue T, Miyake T, Sawa M. Kawahata W, et al. Among authors: irie t. J Med Chem. 2018 Oct 11;61(19):8917-8933. doi: 10.1021/acs.jmedchem.8b01147. Epub 2018 Sep 28. J Med Chem. 2018. PMID: 30216722

6

Discovery of AS-1763: A Potent, Selective, Noncovalent, and Orally Available Inhibitor of Bruton's Tyrosine Kinase.

Kawahata W, Asami T, Kiyoi T, Irie T, Kashimoto S, Furuichi H, Sawa M. Kawahata W, et al. Among authors: irie t. J Med Chem. 2021 Oct 14;64(19):14129-14141. doi: 10.1021/acs.jmedchem.1c01279. Epub 2021 Sep 16. J Med Chem. 2021. PMID: 34529443

7

Discovery of AS-0141, a Potent and Selective Inhibitor of CDC7 Kinase for the Treatment of Solid Cancers.

Irie T, Asami T, Sawa A, Uno Y, Taniyama C, Funakoshi Y, Masai H, Sawa M. Irie T, et al. J Med Chem. 2021 Oct 14;64(19):14153-14164. doi: 10.1021/acs.jmedchem.1c01319. Epub 2021 Oct 5. J Med Chem. 2021. PMID: 34607435

8

CDC7 kinase inhibitors: a survey of recent patent literature (2017-2022).

Irie T, Sawa M. Irie T, et al. Expert Opin Ther Pat. 2023 Jul-Dec;33(7-8):493-501. doi: 10.1080/13543776.2023.2262138. Epub 2023 Nov 6. Expert Opin Ther Pat. 2023. PMID: 37735909 Review.

9

Reply to "Levacetylleucine a game changer for Niemann-Pick disease type-C".

Matsuo M, Ishitsuka Y, Irie T. Matsuo M, et al. Among authors: irie t. Brain Dev. 2025 Jan 6;47(1):104301. doi: 10.1016/j.braindev.2024.104301. Online ahead of print. Brain Dev. 2025. PMID: 39765147 No abstract available.

10

The Importance and Discovery of Highly Connected Covalent Organic Framework Net Topologies.

Irie T, Das S, Fang Q, Negishi Y. Irie T, et al. J Am Chem Soc. 2025 Jan 15;147(2):1367-1380. doi: 10.1021/jacs.4c14458. Epub 2025 Jan 2. J Am Chem Soc. 2025. PMID: 39745262 Review.

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