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106 results

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Temozolomide pharmacodynamics in patients with metastatic melanoma: dna damage and activity of repair enzymes O6-alkylguanine alkyltransferase and poly(ADP-ribose) polymerase-1.
Plummer ER, Middleton MR, Jones C, Olsen A, Hickson I, McHugh P, Margison GP, McGown G, Thorncroft M, Watson AJ, Boddy AV, Calvert AH, Harris AL, Newell DR, Curtin NJ. Plummer ER, et al. Clin Cancer Res. 2005 May 1;11(9):3402-9. doi: 10.1158/1078-0432.CCR-04-2353. Clin Cancer Res. 2005. PMID: 15867241 Free article. Clinical Trial.
Phase I study of the poly(ADP-ribose) polymerase inhibitor, AG014699, in combination with temozolomide in patients with advanced solid tumors.
Plummer R, Jones C, Middleton M, Wilson R, Evans J, Olsen A, Curtin N, Boddy A, McHugh P, Newell D, Harris A, Johnson P, Steinfeldt H, Dewji R, Wang D, Robson L, Calvert H. Plummer R, et al. Clin Cancer Res. 2008 Dec 1;14(23):7917-23. doi: 10.1158/1078-0432.CCR-08-1223. Clin Cancer Res. 2008. PMID: 19047122 Free PMC article. Clinical Trial.
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.
Wang AT, Sengerová B, Cattell E, Inagawa T, Hartley JM, Kiakos K, Burgess-Brown NA, Swift LP, Enzlin JH, Schofield CJ, Gileadi O, Hartley JA, McHugh PJ. Wang AT, et al. Among authors: mchugh pj. Genes Dev. 2011 Sep 1;25(17):1859-70. doi: 10.1101/gad.15699211. Genes Dev. 2011. PMID: 21896658 Free PMC article.
Antiviral activity of bone morphogenetic proteins and activins.
Eddowes LA, Al-Hourani K, Ramamurthy N, Frankish J, Baddock HT, Sandor C, Ryan JD, Fusco DN, Arezes J, Giannoulatou E, Boninsegna S, Chevaliez S, Owens BMJ, Sun CC, Fabris P, Giordani MT, Martines D, Vukicevic S, Crowe J, Lin HY, Rehwinkel J, McHugh PJ, Binder M, Babitt JL, Chung RT, Lawless MW, Armitage AE, Webber C, Klenerman P, Drakesmith H. Eddowes LA, et al. Among authors: mchugh pj. Nat Microbiol. 2019 Feb;4(2):339-351. doi: 10.1038/s41564-018-0301-9. Epub 2018 Dec 3. Nat Microbiol. 2019. PMID: 30510168 Free PMC article.
SNM1A is crucial for efficient repair of complex DNA breaks in human cells.
Swift LP, Lagerholm BC, Henderson LR, Ratnaweera M, Baddock HT, Sengerova B, Lee S, Cruz-Migoni A, Waithe D, Renz C, Ulrich HD, Newman JA, Schofield CJ, McHugh PJ. Swift LP, et al. Among authors: mchugh pj. Nat Commun. 2024 Jun 25;15(1):5392. doi: 10.1038/s41467-024-49583-5. Nat Commun. 2024. PMID: 38918391 Free PMC article.
CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.
Iyama T, Lee SY, Berquist BR, Gileadi O, Bohr VA, Seidman MM, McHugh PJ, Wilson DM 3rd. Iyama T, et al. Among authors: mchugh pj. Nucleic Acids Res. 2015 Jan;43(1):247-58. doi: 10.1093/nar/gku1279. Epub 2014 Dec 10. Nucleic Acids Res. 2015. PMID: 25505141 Free PMC article.
EXD2 promotes homologous recombination by facilitating DNA end resection.
Broderick R, Nieminuszczy J, Baddock HT, Deshpande R, Gileadi O, Paull TT, McHugh PJ, Niedzwiedz W. Broderick R, et al. Among authors: mchugh pj. Nat Cell Biol. 2016 Mar;18(3):271-280. doi: 10.1038/ncb3303. Epub 2016 Jan 25. Nat Cell Biol. 2016. PMID: 26807646 Free PMC article.
106 results