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Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.
Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K. Obayashi E, et al. Among authors: zhang f. Cell Rep. 2017 Mar 14;18(11):2651-2663. doi: 10.1016/j.celrep.2017.02.052. Cell Rep. 2017. PMID: 28297669 Free PMC article.
The C-terminal region of eukaryotic translation initiation factor 3a (eIF3a) promotes mRNA recruitment, scanning, and, together with eIF3j and the eIF3b RNA recognition motif, selection of AUG start codons.
Chiu WL, Wagner S, Herrmannová A, Burela L, Zhang F, Saini AK, Valásek L, Hinnebusch AG. Chiu WL, et al. Among authors: zhang f. Mol Cell Biol. 2010 Sep;30(18):4415-34. doi: 10.1128/MCB.00280-10. Epub 2010 Jun 28. Mol Cell Biol. 2010. PMID: 20584985 Free PMC article.
Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex.
Saini AK, Nanda JS, Martin-Marcos P, Dong J, Zhang F, Bhardwaj M, Lorsch JR, Hinnebusch AG. Saini AK, et al. Among authors: zhang f. Nucleic Acids Res. 2014 Sep;42(15):9623-40. doi: 10.1093/nar/gku653. Epub 2014 Aug 11. Nucleic Acids Res. 2014. PMID: 25114053 Free PMC article.
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