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Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
Foo TK, Tischkowitz M, Simhadri S, Boshari T, Zayed N, Burke KA, Berman SH, Blecua P, Riaz N, Huo Y, Ding YC, Neuhausen SL, Weigelt B, Reis-Filho JS, Foulkes WD, Xia B. Foo TK, et al. Among authors: simhadri s. Oncogene. 2017 Jul 20;36(29):4161-4170. doi: 10.1038/onc.2017.46. Epub 2017 Mar 20. Oncogene. 2017. PMID: 28319063 Free PMC article.
PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response.
Simhadri S, Vincelli G, Huo Y, Misenko S, Foo TK, Ahlskog J, Sørensen CS, Oakley GG, Ganesan S, Bunting SF, Xia B. Simhadri S, et al. Oncogene. 2019 Mar;38(10):1585-1596. doi: 10.1038/s41388-018-0535-2. Epub 2018 Oct 18. Oncogene. 2019. PMID: 30337689 Free PMC article.
Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice.
Simhadri S, Peterson S, Patel DS, Huo Y, Cai H, Bowman-Colin C, Miller S, Ludwig T, Ganesan S, Bhaumik M, Bunting SF, Jasin M, Xia B. Simhadri S, et al. J Biol Chem. 2014 Aug 29;289(35):24617-29. doi: 10.1074/jbc.M114.566141. Epub 2014 Jul 11. J Biol Chem. 2014. PMID: 25016020 Free PMC article.
Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage.
Ginjala V, Rodriguez-Colon L, Ganguly B, Gangidi P, Gallina P, Al-Hraishawi H, Kulkarni A, Tang J, Gheeya J, Simhadri S, Yao M, Xia B, Ganesan S. Ginjala V, et al. Among authors: simhadri s. Sci Rep. 2017 Nov 30;7(1):16613. doi: 10.1038/s41598-017-16480-5. Sci Rep. 2017. PMID: 29192276 Free PMC article.
20 results