Roth AB - Search Results

1

Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling.

Moisan A, Gubler M, Zhang JD, Tessier Y, Dumong Erichsen K, Sewing S, Gérard R, Avignon B, Huber S, Benmansour F, Chen X, Villaseñor R, Braendli-Baiocco A, Festag M, Maunz A, Singer T, Schuler F, Roth AB. Moisan A, et al. Among authors: roth ab. Mol Ther Nucleic Acids. 2017 Mar 17;6:89-105. doi: 10.1016/j.omtn.2016.11.006. Epub 2016 Dec 10. Mol Ther Nucleic Acids. 2017. PMID: 28325303 Free PMC article.

2

Monitoring Cyp2b10 mRNA expression at cessation of 2-year carcinogenesis bioassay in mouse liver provides evidence for a carcinogenic mechanism devoid of human relevance: the dalcetrapib experience.

Hoflack JC, Mueller L, Fowler S, Braendli-Baiocco A, Flint N, Kuhlmann O, Singer T, Roth A. Hoflack JC, et al. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):355-65. doi: 10.1016/j.taap.2012.01.014. Epub 2012 Jan 28. Toxicol Appl Pharmacol. 2012. PMID: 22293087

3

A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects.

Kustermann S, Boess F, Buness A, Schmitz M, Watzele M, Weiser T, Singer T, Suter L, Roth A. Kustermann S, et al. Toxicol In Vitro. 2013 Aug;27(5):1589-95. doi: 10.1016/j.tiv.2012.08.019. Epub 2012 Aug 28. Toxicol In Vitro. 2013. PMID: 22954529

4

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity.

Kostadinova R, Boess F, Applegate D, Suter L, Weiser T, Singer T, Naughton B, Roth A. Kostadinova R, et al. Toxicol Appl Pharmacol. 2013 Apr 1;268(1):1-16. doi: 10.1016/j.taap.2013.01.012. Epub 2013 Jan 23. Toxicol Appl Pharmacol. 2013. PMID: 23352505

5

Effect of GLP1R agonists taspoglutide and liraglutide on primary thyroid C-cells from rodent and man.

Boess F, Bertinetti-Lapatki C, Zoffmann S, George C, Pfister T, Roth A, Lee SM, Thasler WE, Singer T, Suter L. Boess F, et al. J Mol Endocrinol. 2013 Apr 12;50(3):325-36. doi: 10.1530/JME-12-0186. Print 2013 Jun. J Mol Endocrinol. 2013. PMID: 23463748

6

Data mining reveals a network of early-response genes as a consensus signature of drug-induced in vitro and in vivo toxicity.

Zhang JD, Berntenis N, Roth A, Ebeling M. Zhang JD, et al. Pharmacogenomics J. 2014 Jun;14(3):208-16. doi: 10.1038/tpj.2013.39. Epub 2013 Nov 12. Pharmacogenomics J. 2014. PMID: 24217556 Free PMC article.

7

The application of 3D cell models to support drug safety assessment: opportunities & challenges.

Roth A, Singer T. Roth A, et al. Adv Drug Deliv Rev. 2014 Apr;69-70:179-89. doi: 10.1016/j.addr.2013.12.005. Epub 2013 Dec 27. Adv Drug Deliv Rev. 2014. PMID: 24378580 Review.

8

A real-time impedance-based screening assay for drug-induced vascular leakage.

Kustermann S, Manigold T, Ploix C, Skubatz M, Heckel T, Hinton H, Weiser T, Singer T, Suter L, Roth A. Kustermann S, et al. Toxicol Sci. 2014 Apr;138(2):333-43. doi: 10.1093/toxsci/kft336. Epub 2014 Jan 2. Toxicol Sci. 2014. PMID: 24385420

9

Minimizing DILI risk in drug discovery - A screening tool for drug candidates.

Schadt S, Simon S, Kustermann S, Boess F, McGinnis C, Brink A, Lieven R, Fowler S, Youdim K, Ullah M, Marschmann M, Zihlmann C, Siegrist YM, Cascais AC, Di Lenarda E, Durr E, Schaub N, Ang X, Starke V, Singer T, Alvarez-Sanchez R, Roth AB, Schuler F, Funk C. Schadt S, et al. Among authors: roth ab. Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):429-37. doi: 10.1016/j.tiv.2015.09.019. Epub 2015 Sep 25. Toxicol In Vitro. 2015. PMID: 26407524

10

Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro.

Nguyen DG, Funk J, Robbins JB, Crogan-Grundy C, Presnell SC, Singer T, Roth AB. Nguyen DG, et al. Among authors: roth ab. PLoS One. 2016 Jul 7;11(7):e0158674. doi: 10.1371/journal.pone.0158674. eCollection 2016. PLoS One. 2016. PMID: 27387377 Free PMC article.

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