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Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.
Metcalf B, Chuang C, Dufu K, Patel MP, Silva-Garcia A, Johnson C, Lu Q, Partridge JR, Patskovska L, Patskovsky Y, Almo SC, Jacobson MP, Hua L, Xu Q, Gwaltney SL 2nd, Yee C, Harris J, Morgan BP, James J, Xu D, Hutchaleelaha A, Paulvannan K, Oksenberg D, Li Z. Metcalf B, et al. Among authors: patel mp. ACS Med Chem Lett. 2017 Jan 23;8(3):321-326. doi: 10.1021/acsmedchemlett.6b00491. eCollection 2017 Mar 9. ACS Med Chem Lett. 2017. PMID: 28337324 Free PMC article.
GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.
Oksenberg D, Dufu K, Patel MP, Chuang C, Li Z, Xu Q, Silva-Garcia A, Zhou C, Hutchaleelaha A, Patskovska L, Patskovsky Y, Almo SC, Sinha U, Metcalf BW, Archer DR. Oksenberg D, et al. Among authors: patel mp. Br J Haematol. 2016 Oct;175(1):141-53. doi: 10.1111/bjh.14214. Epub 2016 Jul 5. Br J Haematol. 2016. PMID: 27378309 Free article.
A phase 1/2 ascending dose study and open-label extension study of voxelotor in patients with sickle cell disease.
Howard J, Hemmaway CJ, Telfer P, Layton DM, Porter J, Awogbade M, Mant T, Gretler DD, Dufu K, Hutchaleelaha A, Patel M, Siu V, Dixon S, Landsman N, Tonda M, Lehrer-Graiwer J. Howard J, et al. Blood. 2019 Apr 25;133(17):1865-1875. doi: 10.1182/blood-2018-08-868893. Epub 2019 Jan 17. Blood. 2019. PMID: 30655275 Free PMC article. Clinical Trial.
Basic Science and Pathogenesis.
Patel MP, Fan KH, Johnson M, Cetin A, Ali M, Western D, Liu M, Gorijala P, Budde JP, Cohen AD, Lopez OL, Feingold E, Pottier CP, Kamboh MI, Cruchaga C. Patel MP, et al. Alzheimers Dement. 2024 Dec;20 Suppl 1:e092672. doi: 10.1002/alz.092672. Alzheimers Dement. 2024. PMID: 39750896
Have orthodontists changed their retention and follow-up protocols due to contemporary orthodontics? An online survey.
Maltagliati LÁ, Alves Uchôa SMM, Calastro RC, Patel MP, Raphaelli Nahás AC, Pereira da Silva HD, Matias M. Maltagliati LÁ, et al. Among authors: patel mp. J Dent Res Dent Clin Dent Prospects. 2024 Summer;18(3):225-231. doi: 10.34172/joddd.41030. Epub 2024 Sep 7. J Dent Res Dent Clin Dent Prospects. 2024. PMID: 39386122 Free PMC article.
259 results