Sheltzer JM - Search Results

1

CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials.

Lin A, Giuliano CJ, Sayles NM, Sheltzer JM. Lin A, et al. Among authors: sheltzer jm. Elife. 2017 Mar 24;6:e24179. doi: 10.7554/eLife.24179. Elife. 2017. PMID: 28337968 Free PMC article.

2

Single-chromosome Gains Commonly Function as Tumor Suppressors.

Sheltzer JM, Ko JH, Replogle JM, Habibe Burgos NC, Chung ES, Meehl CM, Sayles NM, Passerini V, Storchova Z, Amon A. Sheltzer JM, et al. Cancer Cell. 2017 Feb 13;31(2):240-255. doi: 10.1016/j.ccell.2016.12.004. Epub 2017 Jan 12. Cancer Cell. 2017. PMID: 28089890 Free PMC article.

3

MELK expression correlates with tumor mitotic activity but is not required for cancer growth.

Giuliano CJ, Lin A, Smith JC, Palladino AC, Sheltzer JM. Giuliano CJ, et al. Among authors: sheltzer jm. Elife. 2018 Feb 8;7:e32838. doi: 10.7554/eLife.32838. Elife. 2018. PMID: 29417930 Free PMC article.

4

Systematic identification of mutations and copy number alterations associated with cancer patient prognosis.

Smith JC, Sheltzer JM. Smith JC, et al. Among authors: sheltzer jm. Elife. 2018 Dec 11;7:e39217. doi: 10.7554/eLife.39217. Elife. 2018. PMID: 30526857 Free PMC article.

5

Generating Single Cell-Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9.

Giuliano CJ, Lin A, Girish V, Sheltzer JM. Giuliano CJ, et al. Among authors: sheltzer jm. Curr Protoc Mol Biol. 2019 Sep;128(1):e100. doi: 10.1002/cpmb.100. Curr Protoc Mol Biol. 2019. PMID: 31503414 Free PMC article.

6

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials.

Lin A, Giuliano CJ, Palladino A, John KM, Abramowicz C, Yuan ML, Sausville EL, Lukow DA, Liu L, Chait AR, Galluzzo ZC, Tucker C, Sheltzer JM. Lin A, et al. Among authors: sheltzer jm. Sci Transl Med. 2019 Sep 11;11(509):eaaw8412. doi: 10.1126/scitranslmed.aaw8412. Sci Transl Med. 2019. PMID: 31511426 Free PMC article.

7

Micronuclei-based model system reveals functional consequences of chromothripsis in human cells.

Kneissig M, Keuper K, de Pagter MS, van Roosmalen MJ, Martin J, Otto H, Passerini V, Campos Sparr A, Renkens I, Kropveld F, Vasudevan A, Sheltzer JM, Kloosterman WP, Storchova Z. Kneissig M, et al. Among authors: sheltzer jm. Elife. 2019 Nov 28;8:e50292. doi: 10.7554/eLife.50292. Elife. 2019. PMID: 31778112 Free PMC article.

8

Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer.

Vasudevan A, Baruah PS, Smith JC, Wang Z, Sayles NM, Andrews P, Kendall J, Leu J, Chunduri NK, Levy D, Wigler M, Storchová Z, Sheltzer JM. Vasudevan A, et al. Among authors: sheltzer jm. Dev Cell. 2020 Feb 24;52(4):413-428.e6. doi: 10.1016/j.devcel.2020.01.034. Dev Cell. 2020. PMID: 32097652 Free PMC article.

9

Discovering and validating cancer genetic dependencies: approaches and pitfalls.

Lin A, Sheltzer JM. Lin A, et al. Among authors: sheltzer jm. Nat Rev Genet. 2020 Nov;21(11):671-682. doi: 10.1038/s41576-020-0247-7. Epub 2020 Jun 19. Nat Rev Genet. 2020. PMID: 32561862 Review.

10

A CRISPR Competition Assay to Identify Cancer Genetic Dependencies.

Girish V, Sheltzer JM. Girish V, et al. Among authors: sheltzer jm. Bio Protoc. 2020 Jul 20;10(14):e3682. doi: 10.21769/BioProtoc.3682. eCollection 2020 Jul 20. Bio Protoc. 2020. PMID: 33659353 Free PMC article.

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