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Higher levels of IL-6, CD4 turnover and Treg frequency are already present before cART in HIV-infected subjects with later low CD4 recovery.
Rosado-Sánchez I, Jarrín I, Pozo-Balado MM, de Pablo-Bernal RS, Herrero-Fernández I, Alvarez-Ríos AI, Rodríguez-Gallego E, Genebat M, Vera M, Berenguer J, Martín ML, Bernal E, Vidal F, Blanco J, Leal M, Pacheco YM. Rosado-Sánchez I, et al. Among authors: leal m. Antiviral Res. 2017 Jun;142:76-82. doi: 10.1016/j.antiviral.2017.03.015. Epub 2017 Mar 24. Antiviral Res. 2017. PMID: 28343846
Severe immune dysregulation affects CD4⁺CD25(hi)FoxP3⁺ regulatory T cells in HIV-infected patients with low-level CD4 T-cell repopulation despite suppressive highly active antiretroviral therapy.
Méndez-Lagares G, Pozo-Balado MM, Genebat M, García Pergañeda A, Leal M, Pacheco YM. Méndez-Lagares G, et al. Among authors: leal m. J Infect Dis. 2012 May 15;205(10):1501-9. doi: 10.1093/infdis/jis230. Epub 2012 Mar 28. J Infect Dis. 2012. PMID: 22457273
Maintenance of virologic efficacy and decrease in levels of β2-microglobulin, soluble CD40L and soluble CD14 after switching previously treated HIV-infected patients to an NRTI-sparing dual therapy.
Romero-Sánchez MC, Alvarez-Ríos AI, Bernal-Morell E, Genebat M, Vera F, Benhnia MR, Bravo-Urbieta J, Galera-Peñaranda C, de Pablo-Bernal RS, Abad-Carrillo MA, Leal M, Ruiz-Mateos E; VIH-GEMUVIH Región de Murcia Study Group. Romero-Sánchez MC, et al. Among authors: leal m. Antiviral Res. 2014 Nov;111:26-32. doi: 10.1016/j.antiviral.2014.08.011. Epub 2014 Aug 27. Antiviral Res. 2014. PMID: 25173576 Clinical Trial.
CCR5+ CD8 T-cell levels and monocyte activation precede the onset of acute coronary syndrome in HIV-infected patients on antiretroviral therapy.
Tarancon-Diez L, De Pablo-Bernal RS, Álvarez-Rios AI, Rosado-Sánchez I, Dominguez-Molina B, Genebat M, Pacheco YM, Jiménez JL, Muñoz-Fernández MÁ, Ruiz-Mateos E, Leal M. Tarancon-Diez L, et al. Among authors: leal m. Thromb Haemost. 2017 Jun 2;117(6):1141-1149. doi: 10.1160/TH16-11-0867. Epub 2017 Mar 9. Thromb Haemost. 2017. PMID: 28276569
A baseline metabolomic signature is associated with immunological CD4+ T-cell recovery after 36 months of antiretroviral therapy in HIV-infected patients.
Rodríguez-Gallego E, Gómez J, Pacheco YM, Peraire J, Viladés C, Beltrán-Debón R, Mallol R, López-Dupla M, Veloso S, Alba V, Blanco J, Cañellas N, Rull A, Leal M, Correig X, Domingo P, Vidal F. Rodríguez-Gallego E, et al. Among authors: leal m. AIDS. 2018 Mar 13;32(5):565-573. doi: 10.1097/QAD.0000000000001730. AIDS. 2018. PMID: 29280761 Free PMC article.
An in vitro system of autologous lymphocytes culture that allows the study of homeostatic proliferation mechanisms in human naive CD4 T-cells.
Rosado-Sánchez I, González-Magaña A, Pozo-Balado MM, Herrero-Fernández I, Polaino MJ, Rodríguez-Méndez MM, González-Escribano MF, Leal M, Pacheco YM. Rosado-Sánchez I, et al. Among authors: leal m. Lab Invest. 2018 Apr;98(4):500-511. doi: 10.1038/s41374-017-0006-3. Epub 2018 Jan 18. Lab Invest. 2018. PMID: 29348565 Free article.
1,444 results