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Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation.
Parker LJ, Italiano LC, Morton CJ, Hancock NC, Ascher DB, Aitken JB, Harris HH, Campomanes P, Rothlisberger U, De Luca A, Lo Bello M, Ang WH, Dyson PJ, Parker MW. Parker LJ, et al. Among authors: morton cj. Chemistry. 2011 Jul 4;17(28):7806-16. doi: 10.1002/chem.201100586. Epub 2011 Jun 16. Chemistry. 2011. PMID: 21681839
Oncogenic protein interfaces: small molecules, big challenges.
Nero TL, Morton CJ, Holien JK, Wielens J, Parker MW. Nero TL, et al. Among authors: morton cj. Nat Rev Cancer. 2014 Apr;14(4):248-62. doi: 10.1038/nrc3690. Epub 2014 Mar 13. Nat Rev Cancer. 2014. PMID: 24622521 Review.
The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.
Parker LJ, Ciccone S, Italiano LC, Primavera A, Oakley AJ, Morton CJ, Hancock NC, Bello ML, Parker MW. Parker LJ, et al. Among authors: morton cj. J Mol Biol. 2008 Jun 27;380(1):131-44. doi: 10.1016/j.jmb.2008.04.066. Epub 2008 May 4. J Mol Biol. 2008. PMID: 18511072 Free article.
114 results