Jin C - Search Results

1

Development and validation of a high-throughput calcium mobilization assay for the orphan receptor GPR88.

Decker AM, Gay EA, Mathews KM, Rosa TC, Langston TL, Maitra R, Jin C. Decker AM, et al. Among authors: jin c. J Biomed Sci. 2017 Mar 27;24(1):23. doi: 10.1186/s12929-017-0330-3. J Biomed Sci. 2017. PMID: 28347302 Free PMC article.

2

Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor.

Jin C, Decker AM, Huang XP, Gilmour BP, Blough BE, Roth BL, Hu Y, Gill JB, Zhang XP. Jin C, et al. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87. doi: 10.1021/cn500082p. Epub 2014 May 14. ACS Chem Neurosci. 2014. PMID: 24793972 Free PMC article.

3

Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies.

Jin C, Decker AM, Harris DL, Blough BE. Jin C, et al. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432. doi: 10.1021/acschemneuro.6b00182. Epub 2016 Aug 16. ACS Chem Neurosci. 2016. PMID: 27499251 Free PMC article.

4

Design, synthesis and pharmacological evaluation of 4-hydroxyphenylglycine and 4-hydroxyphenylglycinol derivatives as GPR88 agonists.

Jin C, Decker AM, Langston TL. Jin C, et al. Bioorg Med Chem. 2017 Jan 15;25(2):805-812. doi: 10.1016/j.bmc.2016.11.058. Epub 2016 Dec 1. Bioorg Med Chem. 2017. PMID: 27956039 Free PMC article.

5

Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake.

Jin C, Decker AM, Makhijani VH, Besheer J, Darcq E, Kieffer BL, Maitra R. Jin C, et al. J Med Chem. 2018 Aug 9;61(15):6748-6758. doi: 10.1021/acs.jmedchem.8b00566. Epub 2018 Jul 30. J Med Chem. 2018. PMID: 30011199 Free PMC article.

6

Design, Synthesis, and Structure-Activity Relationship Studies of (4-Alkoxyphenyl)glycinamides and Bioisosteric 1,3,4-Oxadiazoles as GPR88 Agonists.

Rahman MT, Decker AM, Langston TL, Mathews KM, Laudermilk L, Maitra R, Ma W, Darcq E, Kieffer BL, Jin C. Rahman MT, et al. Among authors: jin c. J Med Chem. 2020 Dec 10;63(23):14989-15012. doi: 10.1021/acs.jmedchem.0c01581. Epub 2020 Nov 18. J Med Chem. 2020. PMID: 33205975 Free PMC article.

7

Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice.

Narayanan S, Wang S, Vasukuttan V, Vyas Devambatla RK, Dai D, Jin C, Snyder R, Laudermilk L, Runyon SP, Maitra R. Narayanan S, et al. Among authors: jin c. J Med Chem. 2021 Mar 25;64(6):3006-3025. doi: 10.1021/acs.jmedchem.0c01448. Epub 2021 Mar 11. J Med Chem. 2021. PMID: 33705126

8

Evaluation of Amide Bioisosteres Leading to 1,2,3-Triazole Containing Compounds as GPR88 Agonists: Design, Synthesis, and Structure-Activity Relationship Studies.

Rahman MT, Decker AM, Laudermilk L, Maitra R, Ma W, Ben Hamida S, Darcq E, Kieffer BL, Jin C. Rahman MT, et al. Among authors: jin c. J Med Chem. 2021 Aug 26;64(16):12397-12413. doi: 10.1021/acs.jmedchem.1c01075. Epub 2021 Aug 13. J Med Chem. 2021. PMID: 34387471 Free PMC article.

9

Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies.

Guan D, Rahman MT, Gay EA, Vasukuttan V, Mathews KM, Decker AM, Williams AH, Zhan CG, Jin C. Guan D, et al. Among authors: jin c. J Med Chem. 2021 Dec 23;64(24):17866-17886. doi: 10.1021/acs.jmedchem.1c01081. Epub 2021 Dec 2. J Med Chem. 2021. PMID: 34855388 Free PMC article.

10

Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System.

Gay EA, Guan D, Van Voorhies K, Vasukuttan V, Mathews KM, Besheer J, Jin C. Gay EA, et al. Among authors: jin c. J Med Chem. 2022 Jun 9;65(11):7959-7974. doi: 10.1021/acs.jmedchem.2c00508. Epub 2022 May 20. J Med Chem. 2022. PMID: 35594150 Free PMC article.

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