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Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma.
McNeill RS, Canoutas DA, Stuhlmiller TJ, Dhruv HD, Irvin DM, Bash RE, Angus SP, Herring LE, Simon JM, Skinner KR, Limas JC, Chen X, Schmid RS, Siegel MB, Van Swearingen AED, Hadler MJ, Sulman EP, Sarkaria JN, Anders CK, Graves LM, Berens ME, Johnson GL, Miller CR. McNeill RS, et al. Among authors: simon jm. Neuro Oncol. 2017 Oct 19;19(11):1469-1480. doi: 10.1093/neuonc/nox044. Neuro Oncol. 2017. PMID: 28379424 Free PMC article.
Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss.
Liu X, Simon JM, Xie H, Hu L, Wang J, Zurlo G, Fan C, Ptacek TS, Herring L, Tan X, Li M, Baldwin AS, Kim WY, Wu T, Kirschner MW, Gong K, Zhang Q. Liu X, et al. Among authors: simon jm. Mol Cell. 2020 Mar 19;77(6):1294-1306.e5. doi: 10.1016/j.molcel.2020.01.009. Epub 2020 Feb 4. Mol Cell. 2020. PMID: 32023483 Free PMC article.
Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.
Liao C, Zhang Y, Fan C, Herring LE, Liu J, Locasale JW, Takada M, Zhou J, Zurlo G, Hu L, Simon JM, Ptacek TS, Andrianov VG, Loza E, Peng Y, Yang H, Perou CM, Zhang Q. Liao C, et al. Among authors: simon jm. Cancer Discov. 2020 Nov;10(11):1706-1721. doi: 10.1158/2159-8290.CD-20-0288. Epub 2020 Jul 20. Cancer Discov. 2020. PMID: 32690540 Free PMC article.
2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling in cell migration control independent of innate immunity.
Deng Y, Hahn Q, Yu L, Zhu Z, Boyer JA, Wang J, Kong D, Carey LM, Hepperla AJ, Simon JM, Temple B, Zhang Z, Zhang Y, Santos C, Frank JE, Herring LE, Wang X, Dokholyan NV, Campbell SL, Baldwin AS, Damania B, Zhang Q, Liu P. Deng Y, et al. Among authors: simon jm. Sci Adv. 2024 Oct 18;10(42):eado7024. doi: 10.1126/sciadv.ado7024. Epub 2024 Oct 16. Sci Adv. 2024. PMID: 39413198 Free PMC article.
PTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition.
Patel M, Gomez NC, McFadden AW, Moats-Staats BM, Wu S, Rojas A, Sapp T, Simon JM, Smith SV, Kaiser-Rogers K, Davis IJ. Patel M, et al. Among authors: simon jm. Mol Cancer Res. 2014 Nov;12(11):1610-20. doi: 10.1158/1541-7786.MCR-14-0006. Epub 2014 Jul 3. Mol Cancer Res. 2014. PMID: 24994750 Free PMC article.
scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy.
Ocasio JK, Babcock B, Malawsky D, Weir SJ, Loo L, Simon JM, Zylka MJ, Hwang D, Dismuke T, Sokolsky M, Rosen EP, Vibhakar R, Zhang J, Saulnier O, Vladoiu M, El-Hamamy I, Stein LD, Taylor MD, Smith KS, Northcott PA, Colaneri A, Wilhelmsen K, Gershon TR. Ocasio JK, et al. Among authors: simon jm. Nat Commun. 2019 Dec 20;10(1):5829. doi: 10.1038/s41467-019-13657-6. Nat Commun. 2019. PMID: 31863004 Free PMC article.
339 results