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Page 1
Rab7-a novel redox target that modulates inflammatory pain processing.
Kallenborn-Gerhardt W, Möser CV, Lorenz JE, Steger M, Heidler J, Scheving R, Petersen J, Kennel L, Flauaus C, Lu R, Edinger AL, Tegeder I, Geisslinger G, Heide H, Wittig I, Schmidtko A. Kallenborn-Gerhardt W, et al. Among authors: flauaus c. Pain. 2017 Jul;158(7):1354-1365. doi: 10.1097/j.pain.0000000000000920. Pain. 2017. PMID: 28394828
KCa3.1 channels modulate the processing of noxious chemical stimuli in mice.
Lu R, Flauaus C, Kennel L, Petersen J, Drees O, Kallenborn-Gerhardt W, Ruth P, Lukowski R, Schmidtko A. Lu R, et al. Among authors: flauaus c. Neuropharmacology. 2017 Oct;125:386-395. doi: 10.1016/j.neuropharm.2017.08.021. Epub 2017 Aug 18. Neuropharmacology. 2017. PMID: 28823609
Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1.
Kallenborn-Gerhardt W, Metzner K, Lu R, Petersen J, Kuth MS, Heine S, Drees O, Paul M, Becirovic E, Kennel L, Flauaus C, Gross T, Wack G, Hohmann SW, Nemirovski D, Del Turco D, Biel M, Geisslinger G, Michalakis S, Schmidtko A. Kallenborn-Gerhardt W, et al. Among authors: flauaus c. Neuropharmacology. 2020 Jul;171:108087. doi: 10.1016/j.neuropharm.2020.108087. Epub 2020 Apr 6. Neuropharmacology. 2020. PMID: 32272140
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.
Schierle S, Flauaus C, Heitel P, Willems S, Schmidt J, Kaiser A, Weizel L, Goebel T, Kahnt AS, Geisslinger G, Steinhilber D, Wurglics M, Rovati GE, Schmidtko A, Proschak E, Merk D. Schierle S, et al. Among authors: flauaus c. J Med Chem. 2018 Jul 12;61(13):5758-5764. doi: 10.1021/acs.jmedchem.8b00458. Epub 2018 Jun 22. J Med Chem. 2018. PMID: 29878767 Free article.
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase.
Hiesinger K, Kramer JS, Beyer S, Eckes T, Brunst S, Flauaus C, Wittmann SK, Weizel L, Kaiser A, Kretschmer SBM, George S, Angioni C, Heering J, Geisslinger G, Schubert-Zsilavecz M, Schmidtko A, Pogoryelov D, Pfeilschifter J, Hofmann B, Steinhilber D, Schwalm S, Proschak E. Hiesinger K, et al. Among authors: flauaus c. J Med Chem. 2020 Oct 22;63(20):11498-11521. doi: 10.1021/acs.jmedchem.0c00561. Epub 2020 Oct 12. J Med Chem. 2020. PMID: 33044073
Upadacitinib in Crohn's disease.
Dignass A, Esters P, Flauaus C. Dignass A, et al. Among authors: flauaus c. Expert Opin Pharmacother. 2024 Mar;25(4):359-370. doi: 10.1080/14656566.2024.2333964. Epub 2024 Mar 29. Expert Opin Pharmacother. 2024. PMID: 38512115 Review.
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.
Balzulat A, Zhu WF, Flauaus C, Hernandez-Olmos V, Heering J, Sethumadhavan S, Dubiel M, Frank A, Menge A, Hebchen M, Metzner K, Lu R, Lukowski R, Ruth P, Knapp S, Müller S, Steinhilber D, Hänelt I, Stark H, Proschak E, Schmidtko A. Balzulat A, et al. Among authors: flauaus c. Adv Sci (Weinh). 2024 Apr;11(15):e2307237. doi: 10.1002/advs.202307237. Epub 2024 Feb 13. Adv Sci (Weinh). 2024. PMID: 38350720 Free PMC article.