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Experimental evidence of oxidative stress in patients with l-2-hydroxyglutaric aciduria and that l-carnitine attenuates in vitro DNA damage caused by d-2-hydroxyglutaric and l-2-hydroxyglutaric acids.
Rodrigues DGB, de Moura Coelho D, Sitta Â, Jacques CED, Hauschild T, Manfredini V, Bakkali A, Struys EA, Jakobs C, Wajner M, Vargas CR. Rodrigues DGB, et al. Among authors: de moura coelho d. Toxicol In Vitro. 2017 Aug;42:47-53. doi: 10.1016/j.tiv.2017.04.006. Epub 2017 Apr 7. Toxicol In Vitro. 2017. PMID: 28396261 Free article.
Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats.
Pederzolli CD, Mescka CP, Zandoná BR, de Moura Coelho D, Sgaravatti AM, Sgarbi MB, de Souza Wyse AT, Duval Wannmacher CM, Wajner M, Vargas CR, Dutra-Filho CS. Pederzolli CD, et al. Among authors: de souza wyse at, de moura coelho d. Metab Brain Dis. 2010 Jun;25(2):145-54. doi: 10.1007/s11011-010-9190-1. Epub 2010 Apr 30. Metab Brain Dis. 2010. PMID: 20431931
Increased oxidative stress in patients with 3-hydroxy-3-methylglutaric aciduria.
Dos Santos Mello M, Ribas GS, Wayhs CA, Hammerschmidt T, Guerreiro GB, Favenzani JL, Sitta Â, de Moura Coelho D, Wajner M, Vargas CR. Dos Santos Mello M, et al. Among authors: de moura coelho d. Mol Cell Biochem. 2015 Apr;402(1-2):149-55. doi: 10.1007/s11010-014-2322-x. Epub 2015 Jan 4. Mol Cell Biochem. 2015. PMID: 25557019
L-Carnitine supplementation decreases DNA damage in treated MSUD patients.
Mescka CP, Guerreiro G, Hammerschmidt T, Faverzani J, de Moura Coelho D, Mandredini V, Wayhs CA, Wajner M, Dutra-Filho CS, Vargas CR. Mescka CP, et al. Among authors: de moura coelho d. Mutat Res. 2015 May;775:43-7. doi: 10.1016/j.mrfmmm.2015.03.008. Epub 2015 Mar 28. Mutat Res. 2015. PMID: 25867118
Prevention by L-carnitine of DNA damage induced by 3-hydroxy-3-methylglutaric and 3-methylglutaric acids and experimental evidence of lipid and DNA damage in patients with 3-hydroxy-3-methylglutaric aciduria.
Delgado CA, Balbueno Guerreiro GB, Diaz Jacques CE, de Moura Coelho D, Sitta A, Manfredini V, Wajner M, Vargas CR. Delgado CA, et al. Among authors: de moura coelho d. Arch Biochem Biophys. 2019 Jun 15;668:16-22. doi: 10.1016/j.abb.2019.04.008. Epub 2019 Apr 30. Arch Biochem Biophys. 2019. PMID: 31047871
Oxidative damage in mitochondrial fatty acids oxidation disorders patients and the in vitro effect of l-carnitine on DNA damage induced by the accumulated metabolites.
de Moraes MS, Guerreiro G, Sitta A, de Moura Coelho D, Manfredini V, Wajner M, Vargas CR. de Moraes MS, et al. Among authors: de moura coelho d. Arch Biochem Biophys. 2020 Jan 15;679:108206. doi: 10.1016/j.abb.2019.108206. Epub 2019 Nov 22. Arch Biochem Biophys. 2020. PMID: 31760122 Free article.
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