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Page 1
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
Panchaud P, Bruyère T, Blumstein AC, Bur D, Chambovey A, Ertel EA, Gude M, Hubschwerlen C, Jacob L, Kimmerlin T, Pfeifer T, Prade L, Seiler P, Ritz D, Rueedi G. Panchaud P, et al. Among authors: chambovey a. J Med Chem. 2017 May 11;60(9):3755-3775. doi: 10.1021/acs.jmedchem.6b01834. Epub 2017 Apr 24. J Med Chem. 2017. PMID: 28406299
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
Surivet JP, Lange R, Hubschwerlen C, Keck W, Specklin JL, Ritz D, Bur D, Locher H, Seiler P, Strasser DS, Prade L, Kohl C, Schmitt C, Chapoux G, Ilhan E, Ekambaram N, Athanasiou A, Knezevic A, Sabato D, Chambovey A, Gaertner M, Enderlin M, Boehme M, Sippel V, Wyss P. Surivet JP, et al. Among authors: chambovey a. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6705-11. doi: 10.1016/j.bmcl.2012.08.094. Epub 2012 Sep 4. Bioorg Med Chem Lett. 2012. PMID: 23006603
Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket.
Huang CY, Metz A, Lange R, Artico N, Potot C, Hazemann J, Müller M, Dos Santos M, Chambovey A, Ritz D, Eris D, Meyer S, Bourquin G, Sharpe M, Mac Sweeney A. Huang CY, et al. Among authors: chambovey a. Acta Crystallogr D Struct Biol. 2024 Feb 1;80(Pt 2):123-136. doi: 10.1107/S2059798324000329. Epub 2024 Jan 30. Acta Crystallogr D Struct Biol. 2024. PMID: 38289714 Free PMC article.