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Page 1
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
Panchaud P, Bruyère T, Blumstein AC, Bur D, Chambovey A, Ertel EA, Gude M, Hubschwerlen C, Jacob L, Kimmerlin T, Pfeifer T, Prade L, Seiler P, Ritz D, Rueedi G. Panchaud P, et al. Among authors: jacob l. J Med Chem. 2017 May 11;60(9):3755-3775. doi: 10.1021/acs.jmedchem.6b01834. Epub 2017 Apr 24. J Med Chem. 2017. PMID: 28406299
Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria.
Surivet JP, Panchaud P, Specklin JL, Diethelm S, Blumstein AC, Gauvin JC, Jacob L, Masse F, Mathieu G, Mirre A, Schmitt C, Lange R, Tidten-Luksch N, Gnerre C, Seeland S, Herrmann C, Seiler P, Enderlin-Paput M, Mac Sweeney A, Wicki M, Hubschwerlen C, Ritz D, Rueedi G. Surivet JP, et al. Among authors: jacob l. J Med Chem. 2020 Jan 9;63(1):66-87. doi: 10.1021/acs.jmedchem.9b01604. Epub 2019 Dec 24. J Med Chem. 2020. PMID: 31804826
Optimization of LpxC Inhibitor Lead Compounds Focusing on Efficacy and Formulation for High Dose Intravenous Administration.
Panchaud P, Surivet JP, Diethelm S, Blumstein AC, Gauvin JC, Jacob L, Masse F, Mathieu G, Mirre A, Schmitt C, Enderlin-Paput M, Lange R, Gnerre C, Seeland S, Herrmann C, Locher HH, Seiler P, Ritz D, Rueedi G. Panchaud P, et al. Among authors: jacob l. J Med Chem. 2020 Jan 9;63(1):88-102. doi: 10.1021/acs.jmedchem.9b01605. Epub 2019 Dec 23. J Med Chem. 2020. PMID: 31804829
Discovery and Structure-Activity Relationship of Cadazolid: A First-In-Class Quinoxolidinone Antibiotic for the Treatment of Clostridioides difficile Infection.
Rueedi G, Panchaud P, Friedli A, Specklin JL, Hubschwerlen C, Blumstein AC, Caspers P, Enderlin-Paput M, Jacob L, Kohl C, Locher HH, Pfaff P, Schmitt C, Seiler P, Ritz D. Rueedi G, et al. Among authors: jacob l. J Med Chem. 2024 Jun 13;67(11):9465-9484. doi: 10.1021/acs.jmedchem.4c00558. Epub 2024 May 16. J Med Chem. 2024. PMID: 38753983
947 results