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Page 1
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
Panchaud P, Bruyère T, Blumstein AC, Bur D, Chambovey A, Ertel EA, Gude M, Hubschwerlen C, Jacob L, Kimmerlin T, Pfeifer T, Prade L, Seiler P, Ritz D, Rueedi G. Panchaud P, et al. Among authors: seiler p. J Med Chem. 2017 May 11;60(9):3755-3775. doi: 10.1021/acs.jmedchem.6b01834. Epub 2017 Apr 24. J Med Chem. 2017. PMID: 28406299
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
Surivet JP, Lange R, Hubschwerlen C, Keck W, Specklin JL, Ritz D, Bur D, Locher H, Seiler P, Strasser DS, Prade L, Kohl C, Schmitt C, Chapoux G, Ilhan E, Ekambaram N, Athanasiou A, Knezevic A, Sabato D, Chambovey A, Gaertner M, Enderlin M, Boehme M, Sippel V, Wyss P. Surivet JP, et al. Among authors: seiler p. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6705-11. doi: 10.1016/j.bmcl.2012.08.094. Epub 2012 Sep 4. Bioorg Med Chem Lett. 2012. PMID: 23006603
Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.
Surivet JP, Zumbrunn C, Rueedi G, Hubschwerlen C, Bur D, Bruyère T, Locher H, Ritz D, Keck W, Seiler P, Kohl C, Gauvin JC, Mirre A, Kaegi V, Dos Santos M, Gaertner M, Delers J, Enderlin-Paput M, Boehme M. Surivet JP, et al. Among authors: seiler p. J Med Chem. 2013 Sep 26;56(18):7396-415. doi: 10.1021/jm400963y. Epub 2013 Sep 11. J Med Chem. 2013. PMID: 23968485
Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile.
Surivet JP, Zumbrunn C, Rueedi G, Bur D, Bruyère T, Locher H, Ritz D, Seiler P, Kohl C, Ertel EA, Hess P, Gauvin JC, Mirre A, Kaegi V, Dos Santos M, Kraemer S, Gaertner M, Delers J, Enderlin-Paput M, Weiss M, Sube R, Hadana H, Keck W, Hubschwerlen C. Surivet JP, et al. Among authors: seiler p. J Med Chem. 2015 Jan 22;58(2):927-42. doi: 10.1021/jm501590q. Epub 2014 Dec 23. J Med Chem. 2015. PMID: 25494934
Synthesis and Characterization of Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Antibacterial Activity against Gram-Negative Bacteria.
Surivet JP, Zumbrunn C, Bruyère T, Bur D, Kohl C, Locher HH, Seiler P, Ertel EA, Hess P, Enderlin-Paput M, Enderlin-Paput S, Gauvin JC, Mirre A, Hubschwerlen C, Ritz D, Rueedi G. Surivet JP, et al. Among authors: seiler p. J Med Chem. 2017 May 11;60(9):3776-3794. doi: 10.1021/acs.jmedchem.6b01831. Epub 2017 Apr 24. J Med Chem. 2017. PMID: 28406300
Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria.
Surivet JP, Panchaud P, Specklin JL, Diethelm S, Blumstein AC, Gauvin JC, Jacob L, Masse F, Mathieu G, Mirre A, Schmitt C, Lange R, Tidten-Luksch N, Gnerre C, Seeland S, Herrmann C, Seiler P, Enderlin-Paput M, Mac Sweeney A, Wicki M, Hubschwerlen C, Ritz D, Rueedi G. Surivet JP, et al. Among authors: seiler p. J Med Chem. 2020 Jan 9;63(1):66-87. doi: 10.1021/acs.jmedchem.9b01604. Epub 2019 Dec 24. J Med Chem. 2020. PMID: 31804826
Optimization of LpxC Inhibitor Lead Compounds Focusing on Efficacy and Formulation for High Dose Intravenous Administration.
Panchaud P, Surivet JP, Diethelm S, Blumstein AC, Gauvin JC, Jacob L, Masse F, Mathieu G, Mirre A, Schmitt C, Enderlin-Paput M, Lange R, Gnerre C, Seeland S, Herrmann C, Locher HH, Seiler P, Ritz D, Rueedi G. Panchaud P, et al. Among authors: seiler p. J Med Chem. 2020 Jan 9;63(1):88-102. doi: 10.1021/acs.jmedchem.9b01605. Epub 2019 Dec 23. J Med Chem. 2020. PMID: 31804829
In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections.
Locher HH, Seiler P, Chen X, Schroeder S, Pfaff P, Enderlin M, Klenk A, Fournier E, Hubschwerlen C, Ritz D, Kelly CP, Keck W. Locher HH, et al. Among authors: seiler p. Antimicrob Agents Chemother. 2014;58(2):892-900. doi: 10.1128/AAC.01830-13. Epub 2013 Nov 25. Antimicrob Agents Chemother. 2014. PMID: 24277020 Free PMC article.
In Vivo Pharmacodynamic Target Investigation of Two Bacterial Topoisomerase Inhibitors, ACT-387042 and ACT-292706, in the Neutropenic Murine Thigh Model against Streptococcus pneumoniae and Staphylococcus aureus.
Lepak AJ, Seiler P, Surivet JP, Ritz D, Kohl C, Andes DR. Lepak AJ, et al. Among authors: seiler p. Antimicrob Agents Chemother. 2016 May 23;60(6):3626-32. doi: 10.1128/AAC.00363-16. Print 2016 Jun. Antimicrob Agents Chemother. 2016. PMID: 27044547 Free PMC article.
161 results