Bosmans F - Search Results

1

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD. Wingerd JS, et al. Among authors: bosmans f. Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0. Sci Rep. 2017. PMID: 28428547 Free PMC article.

2

Animal toxins influence voltage-gated sodium channel function.

Gilchrist J, Olivera BM, Bosmans F. Gilchrist J, et al. Among authors: bosmans f. Handb Exp Pharmacol. 2014;221:203-29. doi: 10.1007/978-3-642-41588-3_10. Handb Exp Pharmacol. 2014. PMID: 24737238 Free PMC article. Review.

3

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.

Bende NS, Dziemborowicz S, Mobli M, Herzig V, Gilchrist J, Wagner J, Nicholson GM, King GF, Bosmans F. Bende NS, et al. Among authors: bosmans f. Nat Commun. 2014 Jul 11;5:4350. doi: 10.1038/ncomms5350. Nat Commun. 2014. PMID: 25014760 Free PMC article.

4

Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami.

Herzig V, Ikonomopoulou M, Smith JJ, Dziemborowicz S, Gilchrist J, Kuhn-Nentwig L, Rezende FO, Moreira LA, Nicholson GM, Bosmans F, King GF. Herzig V, et al. Among authors: bosmans f. Sci Rep. 2016 Jul 7;6:29538. doi: 10.1038/srep29538. Sci Rep. 2016. PMID: 27383378 Free PMC article.

5

Pharmacological characterisation of the highly Na_V1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I. Deuis JR, et al. Among authors: bosmans f. Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Sci Rep. 2017. PMID: 28106092 Free PMC article.

6

Using voltage-sensor toxins and their molecular targets to investigate Na_V 1.8 gating.

Gilchrist J, Bosmans F. Gilchrist J, et al. Among authors: bosmans f. J Physiol. 2018 May 15;596(10):1863-1872. doi: 10.1113/JP275102. Epub 2018 Jan 6. J Physiol. 2018. PMID: 29193176 Free PMC article. Review.

7

Crystallographic insights into sodium-channel modulation by the β4 subunit.

Gilchrist J, Das S, Van Petegem F, Bosmans F. Gilchrist J, et al. Among authors: bosmans f. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E5016-24. doi: 10.1073/pnas.1314557110. Epub 2013 Dec 2. Proc Natl Acad Sci U S A. 2013. PMID: 24297919 Free PMC article.

8

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop.

Bende NS, Dziemborowicz S, Herzig V, Ramanujam V, Brown GW, Bosmans F, Nicholson GM, King GF, Mobli M. Bende NS, et al. Among authors: bosmans f. FEBS J. 2015 Mar;282(5):904-20. doi: 10.1111/febs.13189. Epub 2015 Jan 23. FEBS J. 2015. PMID: 25559770 Free article.

9

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.

Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF. Klint JK, et al. Among authors: bosmans f. Br J Pharmacol. 2015 May;172(10):2445-58. doi: 10.1111/bph.13081. Epub 2015 Mar 4. Br J Pharmacol. 2015. PMID: 25754331 Free PMC article.

10

Binary architecture of the Nav1.2-β2 signaling complex.

Das S, Gilchrist J, Bosmans F, Van Petegem F. Das S, et al. Among authors: bosmans f. Elife. 2016 Feb 19;5:e10960. doi: 10.7554/eLife.10960. Elife. 2016. PMID: 26894959 Free PMC article.

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