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The immunoproteasome is induced by cytokines and regulates apoptosis in human islets.
Lundh M, Bugliani M, Dahlby T, Chou DH, Wagner B, Ghiasi SM, De Tata V, Chen Z, Lund MN, Davies MJ, Marchetti P, Mandrup-Poulsen T. Lundh M, et al. Among authors: dahlby t. J Endocrinol. 2017 Jun;233(3):369-379. doi: 10.1530/JOE-17-0110. Epub 2017 Apr 24. J Endocrinol. 2017. PMID: 28438776 Free PMC article.
Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-Cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases, and Immunoproteasomal Activity.
Andersen PAK, Petrenko V, Rose PH, Koomen M, Fischer N, Ghiasi SM, Dahlby T, Dibner C, Mandrup-Poulsen T. Andersen PAK, et al. Among authors: dahlby t. Int J Mol Sci. 2020 Dec 23;22(1):83. doi: 10.3390/ijms22010083. Int J Mol Sci. 2020. PMID: 33374803 Free PMC article.
The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets.
Khilji MS, Bresson SE, Verstappen D, Pihl C, Andersen PAK, Agergaard JB, Dahlby T, Bryde TH, Klindt K, Nielsen CK, Walentinsson A, Zivkovic D, Bousquet MP, Tyrberg B, Richardson SJ, Morgan NG, Mandrup-Poulsen T, Marzec MT. Khilji MS, et al. Among authors: dahlby t. Am J Physiol Endocrinol Metab. 2020 Jun 1;318(6):E892-E900. doi: 10.1152/ajpendo.00372.2019. Epub 2020 Apr 7. Am J Physiol Endocrinol Metab. 2020. PMID: 32255680 Free article.
Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling.
Ghiasi SM, Dahlby T, Hede Andersen C, Haataja L, Petersen S, Omar-Hmeadi M, Yang M, Pihl C, Bresson SE, Khilji MS, Klindt K, Cheta O, Perone MJ, Tyrberg B, Prats C, Barg S, Tengholm A, Arvan P, Mandrup-Poulsen T, Marzec MT. Ghiasi SM, et al. Among authors: dahlby t. Diabetes. 2019 Apr;68(4):747-760. doi: 10.2337/db18-0671. Epub 2019 Jan 22. Diabetes. 2019. PMID: 30670477 Free PMC article.
The intermediate proteasome is constitutively expressed in pancreatic beta cells and upregulated by stimulatory, low concentrations of interleukin 1 β.
Khilji MS, Verstappen D, Dahlby T, Burstein Prause MC, Pihl C, Bresson SE, Bryde TH, Keller Andersen PA, Klindt K, Zivkovic D, Bousquet-Dubouch MP, Tyrberg B, Mandrup-Poulsen T, Marzec MT. Khilji MS, et al. Among authors: dahlby t. PLoS One. 2020 Feb 13;15(2):e0222432. doi: 10.1371/journal.pone.0222432. eCollection 2020. PLoS One. 2020. PMID: 32053590 Free PMC article.
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