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The immunoproteasome is induced by cytokines and regulates apoptosis in human islets.
Lundh M, Bugliani M, Dahlby T, Chou DH, Wagner B, Ghiasi SM, De Tata V, Chen Z, Lund MN, Davies MJ, Marchetti P, Mandrup-Poulsen T. Lundh M, et al. Among authors: wagner b. J Endocrinol. 2017 Jun;233(3):369-379. doi: 10.1530/JOE-17-0110. Epub 2017 Apr 24. J Endocrinol. 2017. PMID: 28438776 Free PMC article.
Chemical methods to induce Beta-cell proliferation.
Vetere A, Wagner BK. Vetere A, et al. Int J Endocrinol. 2012;2012:925143. doi: 10.1155/2012/925143. Epub 2012 Jun 28. Int J Endocrinol. 2012. PMID: 22811709 Free PMC article.
Small-molecule inhibition of inflammatory β-cell death.
Lundh M, Scully SS, Mandrup-Poulsen T, Wagner BK. Lundh M, et al. Among authors: wagner bk. Diabetes Obes Metab. 2013 Sep;15 Suppl 3(0 3):176-84. doi: 10.1111/dom.12158. Diabetes Obes Metab. 2013. PMID: 24003935 Free PMC article. Review.
Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling.
Chou DH, Vetere A, Choudhary A, Scully SS, Schenone M, Tang A, Gomez R, Burns SM, Lundh M, Vital T, Comer E, Faloon PW, Dančík V, Ciarlo C, Paulk J, Dai M, Reddy C, Sun H, Young M, Donato N, Jaffe J, Clemons PA, Palmer M, Carr SA, Schreiber SL, Wagner BK. Chou DH, et al. J Am Chem Soc. 2015 Jun 24;137(24):7929-34. doi: 10.1021/jacs.5b04284. Epub 2015 Jun 15. J Am Chem Soc. 2015. PMID: 26042473 Free PMC article.
An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.
Wagner FF, Lundh M, Kaya T, McCarren P, Zhang YL, Chattopadhyay S, Gale JP, Galbo T, Fisher SL, Meier BC, Vetere A, Richardson S, Morgan NG, Christensen DP, Gilbert TJ, Hooker JM, Leroy M, Walpita D, Mandrup-Poulsen T, Wagner BK, Holson EB. Wagner FF, et al. Among authors: wagner bk. ACS Chem Biol. 2016 Feb 19;11(2):363-74. doi: 10.1021/acschembio.5b00640. Epub 2015 Dec 7. ACS Chem Biol. 2016. PMID: 26640968
2,458 results