Chibale K - Search Results

1

Antischistosomal Activity of Pyrido[1,2-a]benzimidazole Derivatives and Correlation with Inhibition of β-Hematin Formation.

Okombo J, Singh K, Mayoka G, Ndubi F, Barnard L, Njogu PM, Njoroge M, Gibhard L, Brunschwig C, Vargas M, Keiser J, Egan TJ, Chibale K. Okombo J, et al. Among authors: chibale k. ACS Infect Dis. 2017 Jun 9;3(6):411-420. doi: 10.1021/acsinfecdis.6b00205. Epub 2017 May 3. ACS Infect Dis. 2017. PMID: 28440625

2

Meclonazepam analogues as potential new antihelmintic agents.

Mahajan A, Kumar V, Mansour NR, Bickle Q, Chibale K. Mahajan A, et al. Among authors: chibale k. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2333-6. doi: 10.1016/j.bmcl.2008.02.077. Epub 2008 Mar 6. Bioorg Med Chem Lett. 2008. PMID: 18343662

3

Reversed chloroquines based on the 3,4-dihydropyrimidin-2(1H)-one scaffold: synthesis and evaluation for antimalarial, beta-haematin inhibition, and cytotoxic activity.

October N, Watermeyer ND, Yardley V, Egan TJ, Ncokazi K, Chibale K. October N, et al. Among authors: chibale k. ChemMedChem. 2008 Nov;3(11):1649-53. doi: 10.1002/cmdc.200800172. ChemMedChem. 2008. PMID: 18846586 No abstract available.

4

Antiplasmodial, beta-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines.

Musonda CC, Yardley V, de Souza RC, Ncokazi K, Egan TJ, Chibale K. Musonda CC, et al. Among authors: chibale k. Org Biomol Chem. 2008 Dec 7;6(23):4446-51. doi: 10.1039/b813007h. Epub 2008 Oct 24. Org Biomol Chem. 2008. PMID: 19005606

5

Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds.

Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Smith PJ, Chibale K. Guantai EM, et al. Among authors: chibale k. Bioorg Med Chem. 2010 Dec 1;18(23):8243-56. doi: 10.1016/j.bmc.2010.10.009. Epub 2010 Oct 31. Bioorg Med Chem. 2010. PMID: 21044845

6

Linear free energy relationships predict coordination and π-stacking interactions of small molecules with ferriprotoporphyrin IX.

Kuter D, Chibale K, Egan TJ. Kuter D, et al. Among authors: chibale k. J Inorg Biochem. 2011 May;105(5):684-92. doi: 10.1016/j.jinorgbio.2011.02.008. Epub 2011 Feb 26. J Inorg Biochem. 2011. PMID: 21450272

7

Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.

Guantai EM, Ncokazi K, Egan TJ, Gut J, Rosenthal PJ, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K. Guantai EM, et al. Among authors: chibale k. J Med Chem. 2011 May 26;54(10):3637-49. doi: 10.1021/jm200149e. Epub 2011 May 5. J Med Chem. 2011. PMID: 21500839 Free PMC article.

8

Effects of highly active novel artemisinin-chloroquinoline hybrid compounds on β-hematin formation, parasite morphology and endocytosis in Plasmodium falciparum.

Feng TS, Guantai EM, Nell M, van Rensburg CE, Ncokazi K, Egan TJ, Hoppe HC, Chibale K. Feng TS, et al. Among authors: chibale k. Biochem Pharmacol. 2011 Aug 1;82(3):236-47. doi: 10.1016/j.bcp.2011.04.018. Epub 2011 May 8. Biochem Pharmacol. 2011. PMID: 21596024

9

Antimalarial pyrido[1,2-a]benzimidazoles.

Ndakala AJ, Gessner RK, Gitari PW, October N, White KL, Hudson A, Fakorede F, Shackleford DM, Kaiser M, Yeates C, Charman SA, Chibale K. Ndakala AJ, et al. Among authors: chibale k. J Med Chem. 2011 Jul 14;54(13):4581-9. doi: 10.1021/jm200227r. Epub 2011 Jun 16. J Med Chem. 2011. PMID: 21644541

10

Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).

Zishiri VK, Joshi MC, Hunter R, Chibale K, Smith PJ, Summers RL, Martin RE, Egan TJ. Zishiri VK, et al. Among authors: chibale k. J Med Chem. 2011 Oct 13;54(19):6956-68. doi: 10.1021/jm2009698. Epub 2011 Sep 13. J Med Chem. 2011. PMID: 21875063

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